Nevirapine can cause serious, life-threatening side effects. These include severe liver problems, skin rash, and skin reactions. The liver and skin problems can happen at any time during treatment, but the time of greatest risk is during the first 18 weeks of treatment.
Stop taking nevirapine and contact your health care provider right away if you have any of the following symptoms that may signal liver problems:
Stop taking nevirapine and contact your health care provider right away if you have a skin rash with any of the following symptoms:
While taking nevirapine, it is important to keep all of your appointments with your health care provider. If your health care provider tells you to stop treatment with nevirapine because of serious liver or skin problems, you should never take nevirapine again.
Nevirapine is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults and children 15 days and older. Nevirapine is always used in combination with other anti-HIV medicines.
Nevirapine is a type of anti-HIV medicine called a non-nucleoside reverse transcriptase inhibitor (NNRTI). NNRTIs work by binding to and blocking HIV reverse transcriptase, an HIV enzyme. This prevents HIV from replicating and lowers the amount of HIV in the blood.
Nevirapine does not cure HIV/AIDS. It is not known if nevirapine reduces the risk of passing HIV to other people.
Before taking nevirapine, tell your health care provider:
Nevirapine comes in the following forms and strengths:
Take nevirapine according to your health care provider’s instructions.
To reduce the risk of skin rash, a low dose of nevirapine is given for the first 14 days of treatment. If you get a skin rash during the first 14 days of nevirapine treatment, call your health care provider right away. Do not increase your nevirapine dose to 2 times a day if you have a rash.
Take nevirapine with or without food. Never take more than one form of nevirapine at the same time.
Nevirapine extended-release tablets are not for use in children less than 6 years of age. The extended-release tablets should be swallowed whole and should not be chewed, crushed, or divided. Do not start taking nevirapine extended-release tablets if you have a rash.
Nevirapine oral suspension is a liquid. Shake it gently before each use, and use an oral dosing syringe or dosing cup to measure the right dose. If the dose is less than 1 teaspoon (5 mL), use a syringe to measure the dose. (Ask your pharmacist for a syringe or dosing cup if you do not have one.) After drinking the medicine, fill the dosing cup with water and drink it to make sure you get all the medicine.
Always take nevirapine in combination with other anti-HIV medicines.
If you take too much nevirapine, contact your local poison control center (1-800-222-1222) or go to the nearest hospital emergency room right away.
For more information on how to take nevirapine, see the FDA drug labels for nevirapine immediate-release tablets (brand name: Viramune), nevirapine extended-release tablets (brand name: Viramune XR), and nevirapine oral suspension (brand name: Viramune), from DailyMed. (DailyMed is a federal website that includes the most recent drug labels submitted to FDA.)
Take the missed dose as soon as you remember it. But if it is almost time for your next dose, skip the missed dose and just take your next dose at the regular time. Do not take two doses at the same time to make up for a missed dose. If you stop taking nevirapine for more than 7 days, ask your health care provider how much to take before you start taking it again.
Nevirapine can cause serious, life-threatening side effects. These include severe liver problems, skin rash, and skin reactions. The liver and skin problems can happen at any time during treatment, but the time of greatest risk is during the first 18 weeks of treatment. (See the WARNING above.)
Other possible side effects of nevirapine include:
Tell your health care provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of nevirapine. Ask your health care provider or pharmacist for more information on possible side effects of nevirapine.
More information about nevirapine is available:
Last Reviewed: May 22, 2014
Last Updated: May 22, 2014