Truvada can cause serious, life-threatening side effects. These include lactic acidosis (buildup of lactic acid in the blood) and liver problems.
Contact your health care provider right away if you have any of the following symptoms that may signal lactic acidosis:
- Weakness or tiredness.
- Unusual (not normal) muscle pain.
- Trouble breathing.
- Stomach pain with nausea and vomiting.
- Hands or feet that feel cold or turn blue.
- Dizziness or lightheadedness.
- Fast or irregular heartbeat.
Contact your health care provider right away if you have any of the following symptoms that may signal liver problems:
- Yellowing of your skin or the whites of your eyes (jaundice).
- Dark-colored urine.
- Light-colored bowel movements.
- Loss of appetite for several days or longer.
- Pain in the stomach area (abdominal pain).
Truvada is not approved for the treatment of chronic hepatitis B virus (HBV) infection. If you have both HIV and HBV infection and take Truvada, your HBV infection may get worse (flare up) if you stop taking Truvada. The HBV drug adefovir dipivoxil (brand name: Hepsera) should not be taken with Truvada.
Do not take Truvada to reduce the risk of getting HIV—also called pre-exposure prophylaxis or PrEP—unless you are confirmed to be HIV negative.
While taking Truvada, it is important to keep all of your appointments with your health care provider.
What is Truvada?
Truvada is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the following uses:
- To treat HIV infection in adults and adolescents 12 years of age or older weighing at least 35 kg. When Truvada is used to treat HIV infection, the medicine is always used in combination with other HIV medicines.
- To reduce the risk of HIV infection in adults who are HIV-negative and at substantial risk of HIV infection. This method to prevent HIV infection is called pre-exposure prophylaxis or PrEP. For more details about which people can take PrEP, visit the Centers for Disease Control and Prevention’s (CDC’S) PrEP 101 webpage. Because Truvada does not always prevent HIV infection, Truvada used for PrEP should always be combined with other prevention options, such as condoms.
Truvada contains the following two different medicines combined in one pill:
- Emtricitabine (brand name: Emtriva) – an HIV medicine called a nucleoside reverse transcriptase inhibitor (NRTI).
- Tenofovir disoproxil fumarate (brand name: Viread) – another HIV medicine (also an NRTI).
NRTIs block an HIV enzyme called reverse transcriptase. (An enzyme is a protein that starts or increases the speed of a chemical reaction.) By blocking reverse transcriptase, the two drugs in combination prevent HIV from multiplying and can reduce the amount of HIV in the body.
Truvada does not cure HIV/AIDS. People with HIV should stay on continuous HIV treatment as directed by their health care provider and should take steps to avoid passing HIV to others (for example, using a condom during sex).
What should I tell my health care provider before taking Truvada?
Before taking Truvada, tell your health care provider:
- If you are allergic to either of the HIV medicines in Truvada (emtricitabine or tenofovir disoproxil fumarate) or any other medicines.
- If you have liver problems, including HBV infection.
- If you have kidney problems or are undergoing kidney dialysis.
- If you have bone problems.
- If you have any other medical conditions.
- If you are pregnant or plan to become pregnant. Whether Truvada can harm an unborn baby is unknown.
- If you are breastfeeding or plan to breastfeed. Do not breastfeed if you are infected with HIV or are taking Truvada.
- About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Truvada may affect the way other medicines or products work, and other medicines or products may affect how Truvada works. Taking Truvada together with certain medicines or products may cause serious side effects.
Before taking Truvada to reduce your risk of getting HIV, you must get tested to be sure you are HIV negative. Do not take Truvada to reduce the risk of getting HIV unless you are confirmed to be HIV negative.
Before taking Truvada to reduce your risk of getting HIV, also tell your health care provider:
- If you had a flu-like illness within the last month before starting Truvada. If you have flu-like symptoms, you could have recently become infected with HIV. Symptoms of new HIV infection include: tiredness, fever, sweating a lot (especially at night), rash, vomiting, diarrhea, joint or muscle aches, headache, sore throat, or enlarged lymph nodes in the neck or groin.
- If you think that you were exposed to HIV. Your health care provider may want to do more tests to be sure you are still HIV negative.
How should I take Truvada?
Truvada comes in tablet form. Each tablet contains:
- 200 mg emtricitabine (brand name: Emtriva).
- 300 mg tenofovir disoproxil fumarate (brand name: Viread).
Take Truvada according to your health care provider’s instructions.
Take Truvada with or without food at the same time each day.
If you take Truvada to reduce your risk of getting HIV, you will get tested for HIV at least every 3 months. Truvada used for PrEP must be taken every day to give the best protection against HIV infection. Always combine use of Truvada with other prevention methods, such as condoms.
If you take too much Truvada, contact your health care provider or local poison control center (1-800-222-1222) right away or go to the nearest hospital emergency room.
For more information on how to take Truvada, see the FDA drug label from DailyMed. (DailyMed is a federal website that includes the most recent drug labels submitted to FDA.)
What should I do if I forget a dose?
Take the missed dose as soon as you remember it. But if it is almost time for your next dose, skip the missed dose and just take your next dose at the regular time. Do not take two doses at the same time to make up for a missed dose.
What side effects can Truvada cause?
Truvada can cause serious, life-threatening side effects. These include lactic acidosis (buildup of lactic acid in the blood) and liver problems. (See the WARNING above.)
Other possible side effects of Truvada include:
- New or worsening kidney problems, including kidney failure.
- Bone problems (bone pain, softening, or thinning [osteopenia]).
- Changes in the immune system (immune reconstitution inflammatory syndrome [IRIS]).
- Changes in body fat (lipodystrophy).
Tell your health care provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of Truvada. Ask your health care provider or pharmacist for more information on side effects of Truvada. You may also want to read this fact sheet about HIV medicines and side effects.
You may report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088).
How should Truvada be stored?
- Store Truvada at room temperature, 68°F to 77°F (20°C to 25°C).
- Keep Truvada in its original container and keep the container tightly closed. If the container has a small packet of drying agent (called a desiccant), do not remove it. The desiccant protects the medicine from moisture.
- Do not use Truvada if the original seal over the bottle opening is broken or missing.
- Safely throw away Truvada that is no longer needed or expired (out of date).
- Keep Truvada and all medicines out of reach of children.
Where can I find more information about Truvada?
More information about Truvada is available:
Gilead Sciences, Inc.
The above Patient Version drug summary is based on the following FDA label(s): Tablet (film coated)
Last Reviewed: May 15, 2014
Last Updated: May 15, 2014