Rilpivirine can cause serious, life-threatening side effects. These include depression, mood changes, and liver problems.
Contact your health care provider right away if you have any of the following symptoms of depression or mood changes:
Liver problems can happen in people who take rilpivirine. People with a history of hepatitis B virus (HBV) or hepatitis C virus (HCV) infection or who have certain liver function test changes may have an increased risk of developing new or worsening liver problems while taking rilpivirine. Liver problems have also occurred during treatment with rilpivirine in people without a history of liver disease. People taking rilpivirine may need tests to check liver function before and during treatment with rilpivirine.
While taking rilpivirine, it is important to keep all of your appointments with your health care provider.
Rilpivirine is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults who have never taken HIV medicines before and who have a viral load (number of HIV RNA copies per mL of blood) of 100,000 copies/mL or less at the start of treatment. Rilpivirine is always used in combination with other HIV medicines.
Rilpivirine belongs to a class (group) of HIV drugs called non-nucleoside reverse transcriptase inhibitors (NNRTIs). NNRTIs attach to and block an HIV enzyme called reverse transcriptase. (An enzyme is a protein that starts or increases the speed of a chemical reaction.) By blocking reverse transcriptase, NNRTIs prevent HIV from multiplying and can reduce the amount of HIV in the body.
Rilpivirine does not cure HIV/AIDS. People with HIV should stay on continuous HIV treatment as directed by their health care provider and should take steps to avoid passing HIV to others (for example, always using a condom during sex).
Before taking rilpivirine, tell your health care provider:
Rilpivirine comes in tablet form. Each tablet contains 25 mg rilpivirine (brand name: Edurant).
Take rilpivirine according to your health care provider’s instructions.
Always take rilpivirine with a meal. (A protein drink alone does not replace a meal.)
Always take rilpivirine in combination with other HIV medicines.
If you take too much rilpivirine, contact your health care provider or local poison control center (1-800-222-1222) right away or go to the nearest hospital emergency room.
For more information on how to take rilpivirine, see the FDA drug label from DailyMed. (DailyMed is a federal website that includes the most recent drug labels submitted to FDA.)
If you miss a dose of rilpivirine within 12 hours of the time you usually take it, take your dose with a meal as soon as possible. Then take your next dose at the regularly scheduled time. If you miss a dose by more than 12 hours from the time you usually take it, wait and then take the next dose at the regularly scheduled time.
Rilpivirine can cause serious, life-threatening side effects. These include depression, mood changes, and liver problems. (See the WARNING above.)
Other possible side effects of rilpivirine include:
Tell your health care provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of rilpivirine. Ask your health care provider or pharmacist for more information on possible side effects of rilpivirine. You may also want to read this fact sheet about HIV medicines and side effects.You may report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088).
More information about rilpivirine is available:
Janssen Pharmaceuticals, Inc.
Last Reviewed: May 23, 2014
Last Updated: May 23, 2014