Dolutegravir can cause serious, life-threatening side effects. These include allergic reactions.
Contact your health care provider right away if you have a rash.
Stop taking dolutegravir and contact your health care provider right away if you have a rash with any of the following symptoms:
- General ill feeling.
- Extreme tiredness.
- Muscle or joint aches.
- Blisters or sores in your mouth.
- Blisters or peeling skin.
- Redness or swelling of your eyes.
- Swelling of your mouth, face, lips, or tongue.
- Trouble breathing.
Stop taking dolutegravir and contact your health care provider right away if you have any of the following symptoms that may signal liver problems:
- Yellowing of your skin or whites of your eyes (jaundice).
- Dark or tea-colored urine.
- Pale-colored bowel movements.
- Nausea or vomiting.
- Loss of appetite.
- Pain, aching, or tenderness on your right side below your ribs.
Do not take dolutegravir if you take dofetilide. Taking dolutegravir and dofetilide can cause side effects that may be life threatening.
While taking dolutegravir, it is important to keep all of your appointments with your health care provider.
What is dolutegravir?
Dolutegravir is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults and children 12 years of age and older and weighing at least 88 pounds (40 kilograms). Dolutegravir is always used in combination with other anti-HIV medicines.
Dolutegravir is a type of anti-HIV medicine called an integrase inhibitor. Dolutegravir works by blocking integrase, an HIV enzyme. This prevents HIV from replicating and lowers the amount of HIV in the blood.
Dolutegravir does not cure HIV/AIDS. It is not known if dolutegravir reduces the risk of passing HIV to other people.
What should I tell my health care provider before taking dolutegravir?
Before taking dolutegravir, tell your health care provider:
- If you are allergic to dolutegravir or any other medicines.
- If you have had or currently have liver problems, including hepatitis B virus (HBV) or hepatitis C virus (HCV) infection.
- If you have any other medical conditions.
- If you are pregnant or plan to become pregnant. Whether dolutegravir can harm an unborn baby is not known. Dolutegravir should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
- If you are breastfeeding or plan to breastfeed. Do not breastfeed if you are infected with HIV or are taking dolutegravir.
- About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Dolutegravir may affect the way other medicines or products work, and other medicines or products may affect how dolutegravir works. Taking dolutegravir together with certain medicines or products may cause serious side effects. Do not take dolutegravir if you take dofetilide. Taking dolutegravir and dofetilide can cause side effects that may be life threatening.
How should I take dolutegravir?
Dolutegravir comes in tablet form. Each tablet contains 50 mg dolutegravir (brand name: Tivicay).
Take dolutegravir according to your health care provider’s instructions.
Take dolutegravir by mouth, with or without food. Do not change your dose or stop taking dolutegravir without talking with your health care provider first.
Always take dolutegravir in combination with other anti-HIV medicines.
If you take too much dolutegravir, contact your local poison control center (1-800-222-1222) or go to the nearest hospital emergency room right away.
For more information on how to take dolutegravir, see the FDA drug label
from DailyMed. (DailyMed is a federal website that includes the most recent drug labels submitted to FDA.)
What should I do if I forget a dose?
Take the missed dose as soon as you remember it. But if it is within 4 hours of your next dose, skip the missed dose and just take your next dose at the regular time. Do not take two doses at the same time to make up for a missed dose.
What side effects can dolutegravir cause?
Dolutegravir can cause serious, life-threatening side effects. These include allergic reactions. (See the WARNING above.)
Other possible side effects of dolutegravir include:
- Changes in liver tests. People with a history of HBV or HCV may have an increased risk of developing new or worsening changes in certain liver tests during treatment with dolutegravir.
- Changes in body fat (lipodystrophy).
- Changes in the immune system (immune reconstitution syndrome).
- Trouble sleeping.
Tell your health care provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of dolutegravir. Ask your health care provider or pharmacist for more information on side effects of dolutegravir.
How should dolutegravir be stored?
- Store dolutegravir at room temperature, 68°F to 77°F (20°C to 25°C).
- Keep dolutegravir and all medicines out of reach of children.
Where can I find more information about dolutegravir?
More information about dolutegravir is available:
+44 (0)20 8380 6200 (UK)
The above Patient Version drug summary is based on the following FDA label(s): Tablet (film coated)
Last Reviewed: August 16, 2013
Last Updated: August 23, 2013