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AIDSInfo-at-a-glance

Issue No. 14 | April 09, 2010
A Service of the U.S. Department of Health and Human ServicesView HTML version
News and Features 

AIDSinfo and infoSIDA HONcode Certification Renewed

AIDSinfo and infoSIDA are pleased to announce the renewal of their Health on the Net (HON) code certification through March 2011.

HON is a nonprofit, nongovernmental organization that promotes the distribution of reliable and ethically sound health information on the Internet.

The HONcode is a code of ethical conduct that was developed for health and medical Web sites. HONcode certification is granted to Web sites that adhere to the eight HONcode ethical principles, which include confidentiality and privacy of data, attribution of sources, financial disclosure of Web site contributors, and a clearly displayed advertising policy.

Web sites that are granted HONcode certification are reviewed periodically throughout the year to ensure that compliance with HONcode ethical principles is ongoing.

More information on HONcode certification is available at http://www.HealthOnNet.org.

Study Suggests Poor Immune Recovery Related to Nadir CD4 Count and CD4 Cell Intrinsic Apoptosis

“Although antiretroviral therapy improves immune response, some human immunodeficiency virus-infected patients present unsatisfactory CD4 T cell recovery despite achieving viral suppression, resulting in increased morbidity and mortality. … We included 230 patients who were receiving highly active antiretroviral therapy and who had a viral load <50 copies/mL for >2 years; 95 were "discordant" (case patients; CD4 T cell count always <350 cells/microL), and 135 were "concordant" (control subjects). … Discordant patients showed higher levels of activation markers, mainly in CD4 T cells (p < .001), and higher rates of spontaneous cell death (P < .001). Rates of activation and rates of CD4 T cell death (mainly by intrinsic apoptosis) were the best predictive factors for immune recovery, along with nadir CD4 T cell count. … CD4 T cell apoptosis by the intrinsic pathway represents the determinant mechanism of the unsatisfactory immune recovery and should be targeted to manage therapy for discordant patients. The predictive value of low nadir CD4 T cell count for a poor immune recovery led us to consider starting antiretroviral therapy earlier. No differences were observed among antiretrovirals in terms of immune recovery.”

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