Study Evaluates Monoboosted Lopinavir/ritonavir as Simplified Maintenance Therapy in Virologically Suppressed Children
“[Researchers evaluated monoboosted lopinavir/r] as a strategy to simplify therapy in virologically suppressed patients who are on complex regimens. ...
“Children with two consecutive HIV-RNA below 50 copies/ml at least 3 months apart while on double boosted protease inhibitor (dPI) were switched to monoboosted lopinavir/r (mLPV/r). The previous dPI regimen was resumed within 4 weeks in children who experienced virological failure defined as two HIV-RNA at least 500 or three HIV-RNA at least 50 copies/ml. ...
“Forty children on LPV/r + saquinavir (90%) or LPV/r + indinavir (10%) were enrolled ... . At 48 weeks, none had died or had HIV disease progression. Thirty-one children were on mLPV/r and 29 (72.5%) had HIV-RNA less than 50 copies/ml. Nine resumed dPI due to mLPV/r failure with four achieving undetectable HIV-RNA. Overall, 31 children (82.5%) had HIV-RNA suppression. Predicting factor for failing mLPV/r was baseline HIV-RNA at least 50 copies/ml. No major protease mutations were found. ...
“[Researchers suggest that a randomized] study of simplified mono protease inhibitor therapy in children is warranted.”
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