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HIV Overview

FDA-Approved HIV Medicines

(Last updated 12/10/2014; last reviewed 12/10/2014)

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Treatment with HIV medicines is called antiretroviral therapy (ART). ART is recommended for everyone with HIV. People on ART take a combination of HIV medicines (called an HIV regimen) every day. A person's initial HIV regimen generally includes three HIV medicines from at least two different drug classes

ART can’t cure HIV, but it can help people with HIV live longer, healthier lives. HIV medicines can also reduce the risk of HIV transmission.

The following table lists HIV medicines approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in the United States. The HIV medicines are listed according to drug class and identified by generic and brand names. Click on a drug name to view information on the drug from the AIDSinfo Drug Database.

FDA-Approved HIV Medicines
Drug Class Generic Name
(Other names and acronyms)
Brand Name FDA Approval Date
Nucleoside Reverse Transcriptase Inhibitors (NRTIs)
NRTIs block reverse transcriptase, an enzyme HIV needs to make copies of itself. abacavir 
(abacavir sulfate, ABC)
Ziagen December 17, 1998
didanosine 
(ddI, ddI EC)
Videx October 9, 1991 
Videx EC 
(enteric-coated)
October 31, 2000
emtricitabine
(FTC)
Emtriva July 2, 2003
lamivudine 
(3TC)
Epivir November 17, 1995
stavudine 
(d4T)
Zerit June 24, 1994
tenofovir disoproxil 
fumarate

(tenofovir DF, TDF)
Viread October 26, 2001
zidovudine
(azidothymidine, AZT, ZDV)
Retrovir March 19, 1987
Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs)
NNRTIs bind to and later alter reverse transcriptase, an enzyme HIV needs to make copies of itself.
delavirdine
(delavirdine mesylate, DLV)
Rescriptor
April 4, 1997
efavirenz 
(EFV)
Sustiva September 17, 1998
etravirine 
(ETR)
Intelence
January 18, 2008
nevirapine 
(NVP)
Viramune
June 21, 1996
Viramune XR (extended release)
March 25, 2011
rilpivirine
(rilpivirine hydrochloride, RPV)
Edurant May 20, 2011
Protease Inhibitors (PIs)
PIs block HIV protease, an enzyme HIV needs to make copies of itself
atazanavir
(atazanavir sulfate, ATV)
Reyataz June 20, 2003
darunavir
(darunavir ethanolate, DRV)
Prezista  June 23, 2006
fosamprenavir
(fosamprenavir calcium, FOS-APV, FPV)
Lexiva October 20, 2003
indinavir
(indinavir sulfate, IDV)
Crixivan
March 13, 1996
nelfinavir
(nelfinavir mesylate, NFV)
Viracept
March 14, 1997
ritonavir
(RTV)
Norvir
March 1, 1996
saquinavir
(saquinavir mesylate, SQV)
Invirase
December 6, 1995
tipranavir
(TPV)
Aptivus
June 22, 2005
Fusion Inhibitors
Fusion inhibitors block HIV from entering the CD4 cells of the immune system.
enfuvirtide
(T-20)
Fuzeon
March 13, 2003
Entry Inhibitors
Entry inhibitors block proteins on the CD4 cells that HIV needs to enter the cells.
maraviroc
(MVC)
Selzentry
August 6, 2007
Integrase Inhibitors
Integrase inhibitors block HIV integrase, an enzyme HIV needs to make copies of itself.
dolutegravir
(DTG) 
Tivicay 
August 13, 2013 
elvitegravir
(EVG)
Vitekta September 24, 2014
raltegravir
(raltegravir potassium, RAL)
Isentress
October 12, 2007
Pharmacokinetic Enhancers
Pharmacokinetic enhancers are used in HIV treatment to increase the effectiveness of an HIV medicine included in an HIV regimen.
cobicistat 
(COBI)
Tybost
September 24, 2014
Combination HIV Medicines
Combination HIV medicines contain two or more HIV medicines from one or more drug classes.
abacavir and lamivudine 
(abacavir sulfate / lamivudine, ABC / 3TC)
Epzicom
August 2, 2004
abacavir, dolutegravir, and lamivudine
(abacavir sulfate / dolutegravir sodium / lamivudine, ABC / DTG / 3TC) 
Triumeq  August 22, 2014
abacavir, lamivudine, and zidovudine
(abacavir sulfate / lamivudine / zidovudine, ABC / 3TC / ZDV)
Trizivir
November 14, 2000
efavirenz, emtricitabine, and tenofovir disoproxil fumarate
(efavirenz / emtricitabine / tenofovir, efavirenz / emtricitabine / tenofovir DF, EFV / FTC / TDF)
Atripla July 12, 2006
elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate
(QUAD, EVG / COBI / FTC / TDF)
Stribild August 27, 2012
emtricitabine, rilpivirine, and tenofovir disoproxil fumarate
(emtricitabine / rilpivirine hydrochloride / tenofovir disoproxil fumarate, emtricitabine / rilpivirine / tenofovir, FTC / RPV / TDF)
Complera August 10, 2011
emtricitabine and tenofovir disoproxil fumarate
(emtricitabine / tenofovir, FTC / TDF)
Truvada August 2, 2004
lamivudine and zidovudine
(3TC / ZDV)
Combivir September 27, 1997
lopinavir and ritonavir
(ritonavir-boosted lopinavir, LPV/r, LPV / RTV)
Kaletra September 15, 2000

This fact sheet is based on information from the following sources:

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