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Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents

Appendix A: Key to Acronyms

General Terms

(Last updated:2/12/2013; last reviewed:2/12/2013)

General Terms
 Abbreviation              Full Name
ACTG AIDS Clinical Trials Group
AIDS acquired immune deficiency syndrome
ALT alanine aminotransferase 
ART antiretroviral therapy
ART-CC ART Cohort Collaboration
ARV antiretroviral 
AST aspartate aminotransferase 
AUC area under the curv 
AV  atrioventricular
   
bDNA branched DNA
BID twice daily 
BMD  bone mineral density 
BMI body mass index 
BUN blood urea nitrogen 
   
cap capsule
CAPD chronic ambulatory peritoneal dialysis 
CBC  complete blood count 
CCB  calcium channel blocker 
CDC  Centers for Disease Control and Prevention  
CI  confidence interval 
CKD  chronic kidney disease  
Cmax  maximum plasma concentration 
CME  continuing medical education 
Cmin  minimum plasma concentration 
CMV  cytomegalovirus 
CNICS  Centers for AIDS Research Network of Integrated Clinical Systems 
CNS  central nervous system 
COC  combined oral contraceptives 
CPK  creatine phosphokinase  
CrCl  creatinine clearance 
CSF  cerebrospinal fluid 
CVD  cardiovascular disease 
CYP  cytochrome P 
   
D/M  dual or mixed (tropic) 
D:A:D  Data Collection on Adverse Events of Anti-HIV Drugs Study 
DILI drug-induced liver injury
DM diabetes mellitus 
DMPA  depot medroxyprogesterone acetate 
DOT  directly observed therapy 
DR  delayed release 
DXA  dual-energy x-ray absorptiometry 
   
EBV Epstein-Barr virus 
EC  enteric coated 
ECG  electrocardiogram 
EI  entry inhibitor 
EIA  enzyme immunoassay 
   
FDA  Food and Drug Administration 
FI fusion inhibitor 
   
GHB gamma-hydroxybutyrate 
GI  gastrointestinal 
   
HAD  HIV-associated dementia 
HAV  hepatitis A virus 
HBeAg  hepatitis B e antigen 
HBsAg  hepatitis B surface antigen 
HBV  hepatitis B virus  
HCV  hepatitis C virus  
HD  hemodialysis 
HDL  high-density lipoprotein 
HELLP  hemolysis, elevated liver enzymes, low platelet count (syndrome) 
HHS  Department of Health and Human Services   
HHV  human herpes virus 
HHV-8  human herpes virus-8 
HIV  human immunodeficiency virus 
HIV-1  human immunodeficiency virus type 1 
HIV-2 human immunodeficiency virus type 2 
HIVAN  HIV-associated nephropathy 
HLA  human leukocyte antigen 
HPV  human papilloma virus 
HR  hazard ratio 
HRSA  Health Resource Services Administration 
hsCRP  high-sensitivity C-reactive protein 
HSR  hypersensitivity reaction 
HTLV  human T-cell leukemia virus 
HTLV-1  human T-cell leukemia virus type 1 
HTLV-2 human T-cell leukemia virus type 2
   
IAS-USA  International Antiviral Society-USA 
IC  inhibitory concentration
IDU injection drug user
IFN-γ  interferon-gamma
IGRA interferon-gamma release assay
IL-2  interleukin-2 
IL-6 interleukin-6
IL-7 interleukin-7
IND investigational new drug
INH isoniazid 
inj injection
INR international normalized ratio
INSTI integrase strand transfer inhibitor
IQ inhibitory quotient
IRB Institutional Review Board
IRIS immune reconstitution inflammatory syndrome
IUD intrauterine device
IV Intravenous
   
LDL low-density lipoprotein 
LTBI latent tuberculosis infection 
   
MAC Mycobacterium avium complex 
MDMA methylenedioxymethamphetamine 
mDOT modified directly observed therapy 
MDR multidrug-resistant 
MDRD modification of diet in renal disease (equation) 
MHC major histocompatability complex 
MI myocardial infarction 
msec milliseconds 
MSM men who have sex with men 
MTB Mycobacterium tuberculosis
MTCT mother-to-child transmission 
   
NA-ACCORD  The North American AIDS Cohort Collaboration on Research and Design 
NIH National Institutes of Health 
NNRTI  non-nucleoside reverse transcriptase inhibitor 
NRTI nucleoside reverse transcriptase inhibitor 
   
OAR Office of AIDS Research 
OARAC Office of AIDS Research Advisory Council 
OI opportunistic infection 
   
PAH pulmonary arterial hypertension
PCP Pneumocystis jiroveci pneumonia
PDE5 phosphodiesterase type 5
PegIFN peginterferon
p-gp p-glycoprotein
PI protease inhibitor
PK pharmacokinetic
PMTCT prevention of mother-to-child transmission
PNS peripheral nervous system
PO orally
PPI proton pump inhibitor
PR protease (gene)
PrEP pre-exposure HIV prophylaxis
PT prothrombin time
   
QTc QT corrected for heart rate
   
RT reverse transcriptase (gene)
RT-PCR reverse transcriptase-polymerase chain reaction
 
SJS Stevens-Johnson syndrome
soln solution
SPT skin patch test
STD sexually transmitted disease
SVR sustained virologic response
SWP suggested wholesale price
   
t1/2 half-life
tab tablet
TAM thymidine analogue mutation
TB tuberculosis
TCA tricyclic antidepressant
TDM therapeutic drug monitoring
TEN toxic epidermal necrosis
TG triglyceride
the Panel Panel on Antiretroviral Guidelines for Adults and Adolescents
TID three times daily
   
UDP uridine diphosphate
UGT uridine diphosphate gluconyltransferase
UGT1A1 uridine diphosphate glucuronosyltransferase 1A1
ULN upper limit of normal
   
VPA valproic acid
   
WBC white blood cell
WHO World Health Organization
WITS Women and Infants Transmission Study
   
XDR extensively drug-resistant
XR extended release