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Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection

Management of Children Receiving Antiretroviral Therapy

Overview

(Last updated:2/12/2014; last reviewed:2/12/2014)

In the United States, the vast majority of HIV-infected children are receiving combination antiretroviral therapy (cART), making treatment-experienced children the norm. Changes in the antiretroviral (ARV) regimen and other aspects of the management of treatment-experienced children can be organized into the following categories: (1) modifying ARV regimens in children on effective cART for simplification or improved adverse effect profile; (2) recognizing and managing ARV drug toxicity or intolerance (see Management of Medication Toxicity or Intolerance); (3) recognizing and managing treatment failure; and (4) considerations about interruptions in therapy.