AIDSTRIALS and AIDSDRUGS Defined
The AIDSTRIALS (AIDS Clinical Trials) database provides information about AIDS-related studies of experimental treatments conducted under the Food and Drug Administration's (FDA) investigational new drug (IND) regulations. AIDSTRIALS contains information about clinical trials of agents undergoing evaluation for use against Acquired Immunodeficiency Syndrome (AIDS), HIV infection and AIDS-related opportunistic diseases such as Pneumocystis carinii pneumonia (PCP). Detailed information is supplied by the National Institute for Allergy and Infectious Diseases (NIAID) for trials sponsored by the National Institutes of Health (NIH). Information about non-NIH funded trials undergoing tests for efficacy is furnished by FDA. The companion database, AIDSDRUGS, contains descriptive information about the agents being tested in clinical trials.
AIDSTRIALS and AIDSDRUGS can be accessed by a variety of terminals connected to NLM's computer facility. Connection is established via direct telephone line; the TELENET/SprintNet, TYMNET, or CompuServe nationwide telecommunications networks; or by the Internet.
Searching AIDSTRIALS and AIDSDRUGS
The Information contained in AIDSTRIALS includes the title of the trial, the trial purpose, the agent being tested, the trial phase, diseases studied, patient inclusion and exclusion criteria, trial locations, and whether the trial is open or closed; details of the treatment regimen may also be included. The file may be used to identify trials testing a particular agent or to find open trials in a specific location. If additional information is required about the trial, all records contain a telephone number for contacting the specific trial site or sponsor. If additional information about the agent is being tested is required, the AIDSDRUGS database may be searched using either the drug name, accession number contained in the trial record, or the number of the protocol. AIDSDRUGS may be searched to find out about a new drug, then AIDSTRIALS accessed to search for trials using that drug.
The following represents portions of an AIDSTRIALS record:
After a search of AIDSTRIALS, a user may switch to the AIDSDRUGS database and view descriptive information about the agent used in the clinical trial, such as synonyms for the name including drug trade name, pharmacology, contraindications, adverse reactions, manufacturer, and physical/chemical properties such as molecular composition, formula and weight. It is easy to coordinate searches between the databases since the substance identification number from AIDSDRUGS is present in the AIDSTRIALS record and the protocol numbers from AIDSTRIALS are carried in AIDSDRUGS. As new trials are added to AIDSTRIALS, information will be compiled about the agents and records added to AIDSDRUGS.
AIDSTRIALS and AIDSDRUGS are available for online searching at NLM 24 hours a day, 7 days a week. The entire AIDSDRUGS database and AIDSTRIALS records describing open studies are also available via FTP from the NLM Publications server (nlmpubs.nlm.nih.gov; login as nlmpubs).
For Information about AIDSTRIALS and AIDSDRUGS content and search strategies contact:
Specialized Information Services National Library of Medicine 8600 Rockville Pike Bethesda, MD 20894 (301) 496-3147