Clinical Trials


The Safety of Tenofovir Disoproxil Fumarate Taken With Other Anti-HIV Drugs to Treat HIV-Infected Patients

The recruitment status of this study is unknown.

Verified July 2001

Gilead Sciences

Information provided by (Responsible Party)
NIH AIDS Clinical Trials Information Service Identifier

First received: December 19, 2000
Last updated: June 23, 2005
Last Verified: July 2001
History of Changes


The purpose of this study is to evaluate the safety of tenofovir disoproxil fumarate (tenofovir DF) in combination with other anti-HIV drugs in patients who have participated in other tenofovir DF studies (GS-98-902 or GS-99-907), are able to tolerate the drug at different doses, and may benefit from having tenofovir DF treatment.

Condition Intervention Phase
HIV Infections

Drug : Tenofovir disoproxil fumarate
Phase 3

Study Type: Interventional
Study Design: Primary Purpose: Treatment
Official Title: A Phase 3, Open-Label, Multicenter Study of the Safety of Tenofovir Disoproxil Fumarate Administered in Combination With Other Antiretroviral Agents for the Treatment of HIV-1 Infected Patients

Further study details as provided by NIH AIDS Clinical Trials Information Service:

Detailed Description:

Patients take tenofovir DF in combination with other antiretrovirals.



Ages Eligible for Study: Child, Adult, Senior  
Sexes Eligible for Study: All  
Accepts Healthy Volunteers: No  


Inclusion Criteria
Patients may be eligible for this study if they:

  • Have completed another study on tenofovir DF without toxicity.
  • Are willing to use intrauterine or effective barrier methods of birth control, both men and women, during the study and for 30 days following tenofovir DF treatment.

  • Exclusion Criteria
    Patients will not be eligible for this study if they:
  • Are taking drugs that may damage the kidney (nephrotoxic) including aminoglycoside antibiotics, amphotericin B, cidofovir, cisplatin, foscarnet, IV pentamidine, vancomycin, and oral or IV ganciclovir.
  • Are taking agents that affect kidney function, such as probenecid.
  • Are receiving systemic chemotherapy.
  • Are taking systemic corticosteroids.
  • Are taking experimental drugs except those that are approved by Gilead.
  • Are currently participating in the GS-99-908 or GS-00-912 (expanded access) studies.
  • Are pregnant or breast-feeding.

contacts and locations

Contacts and Locations

Choosing to participate in a study is an important personal decision.Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00007436


United States, California
East Bay AIDS Ctr
Berkeley, California, United States, 94705
Tower ID Med Associates
Los Angeles, California, United States, 90048
Pacific Horizons Med Group
San Francisco, California, United States, 94115
Harbor - UCLA Med Ctr
Torrance, California, United States, 90502
United States, Colorado
Univ of Colorado / Health Science Ctr
Denver, Colorado, United States, 80262
United States, District of Columbia
Physicans Home Service
Washington, District of Columbia, United States, 20037
United States, Florida
Steinhart Medical Associates
Miami, Florida, United States, 33133
Dr Gerald Pierone Jr
Vero Beach, Florida, United States, 32960
United States, Illinois
Northstar Med Clinic
Chicago, Illinois, United States, 60657
United States, Massachusetts
CRI New England
Brookline, Massachusetts, United States, 02146
United States, Minnesota
Univ of Minnesota
Minneapolis, Minnesota, United States, 55455
United States, New York
Univ of Rochester Med Ctr
Rochester, New York, United States, 14642
United States, Oregon
Research & Education Group
Portland, Oregon, United States, 97209
United States, Pennsylvania
Hershey Med Ctr
Hershey, Pennsylvania, United States, 17033
Anderson Clinical Research
Pittsburgh, Pennsylvania, United States, 15221
United States, Rhode Island
Roger Williams Med Ctr
Providence, Rhode Island, United States, 02908
United States, Texas
Southwest Infectious Diseases Associates
Dallas, Texas, United States, 75246
Thomas Street Clinic
Houston, Texas, United States, 77009
United States, Washington
Dr Philip C Craven
Tacoma, Washington, United States, 98405

Sponsors and Collaborators

Gilead Sciences
More Information

More Information

Responsible Party: Gilead Sciences Identifier: NCT00007436   History of Changes  
Other Study ID Numbers: 283F  
Study First Received: December 19, 2000  
Last Updated: June 23, 2005  

Keywords provided by NIH AIDS Clinical Trials Information Service:

Drug Therapy, Combination
Reverse Transcriptase Inhibitors
Anti-HIV Agents

Additional relevant MeSH terms:
HIV Infections
Anti-Retroviral Agents processed this data on July 20, 2018
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