Antiretroviral Switch From Didanosine to Tenofovir in HIV/HCV Co-infected Patients
University of British Columbia
Information provided by (Responsible Party)
University of British Columbia
First received: July 28, 2006
Last updated: October 19, 2009
Last Verified: October 2009
History of Changes
The primary purpose of this study is to evaluate the impact of changing didanosine in an effective anti-HIV regimen to tenofovir on virologic suppression. We hypothesize that, in patients with maximal virologic suppression on a double class regimen (including two NRTIs and an NNRTI or a PI, boosted with RTV or not), a single drug substitution of didanosine for tenofovir will represent a viable strategy without any negative impact on the virologic efficacy of the regimen.
Drug : tenofovir
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:||TEN Switch - An Observational Phase IV Study to Evaluate the Safety and Efficacy of Substituting Tenofovir for Didanosine in Virologically Controlled HIV-infected Patients Co-infected With Hepatitis C Virus.|
Further study details as provided by University of British Columbia:
Primary Outcome Measures
- Virologic Suppression
- HAART adherence, safety, CD4 cell count
|Study Start Date:||July 2006|
|Study Completion Date:||October 2009|
|Primary Completion Date:||October 2009 (Final data collection date for primary outcome measure)|
Primary objective - to determine the impact of changing part of an effective HAART regimen to
tenofovir on maintenance of virologic suppression in HCV co-infected patients.
Secondary objective - to assess the safety and tolerability over 12 weeks in patients switched to tenofovir.
Research Method - This will be a single arm observational study to include 30 subjects. Patients requiring HCV treatment will be assessed and patients receiving didanosine will be clinically evaluated to determine an appropriate NRTI drug switch. Patients who are to switch the didanosine component of their regimen to tenofovir will be eligible to participate in the study and will be followed for a period of observation of up to 4 weeks. All patients will be receiving tenofovir as one capsule, once daily. The primary endpoint will be maintenance of virologic suppression between the Baseline visit and week 12 in the overall study group. Measures of adherence to HAART, safety, tolerability and CD4 cell counts will also be obtained at each study visit, and will constitute secondary study endpoints.
|Ages Eligible for Study:||19 Years and older|
|Sexes Eligible for Study:||All|
|Accepts Healthy Volunteers:||No|
- Be age 19 or older;
- Have a confirmed diagnosis of HIV infection;
- Have a confirmed positive HCV RNA PCR;
- Have two consecutive HIV RNA levels <50 copies/mL with the most recent within the past 3 months;
- Must not exhibit evidence of an acute illness, including an acute opportunistic infection;
- Must not have any evidence of grade 3-4 laboratory abnormalities;
- Must be able and willing to provide informed consent.
- Be receiving investigational drug within 30 days prior to beginning this study;
- If female, be pregnant or breast-feeding;
- In the opinion of the investigator, is unlikely to comply with the study protocol or
Contacts and LocationsChoosing to participate in a study is an important personal decision.Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00358696
Locations Show More
|Pender Community Health Centre|
|Vancouver, British Columbia, Canada|
Sponsors and CollaboratorsUniversity of British Columbia
|Principal Investigator:||Dr. Brian Conway, MD||University of British Columbia|
|Responsible Party:||Dr. Brian Conway, University of British Columbia|
|ClinicalTrials.gov Identifier:||NCT00358696 History of Changes|
|Other Study ID Numbers:||C05-0218|
|Study First Received:||July 28, 2006|
|Last Updated:||October 19, 2009|
Keywords provided by University of British Columbia:tenofovir
hepatitis c virus infection
Additional relevant MeSH terms:
ClinicalTrials.gov processed this data on February 15, 2019
This information is provided by ClinicalTrials.gov.