Clinical Trials


Hepatitis Vaccination in HIV Infection: Role of Adjuvant Interleukin-2 (HEPVACHIV)

The recruitment status of this study is unknown.

Verified October 2007

Aalborg University Hospital

Information provided by (Responsible Party)
Aalborg University Hospital Identifier

First received: March 23, 2007
Last updated: October 31, 2007
Last Verified: October 2007
History of Changes


The response to vaccination for hepatitis is reduced in patients with HIV infection. The hypothesis of the study is that adjuvant interleukin-2 administered subcutaneously at the time of vaccination improves the response rate.

Condition Intervention Phase
HIV Infections
Hepatitis A
Hepatitis B

Biological : Twinrix
Biological : interleukin-2
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Prevention

Further study details as provided by Aalborg University Hospital:

Primary Outcome Measures

  • Antibody response to hepatitis A and hepatitis B

Estimated Enrollment: 80
Study Start Date: March 2007



Ages Eligible for Study: 18 Years and older  
Sexes Eligible for Study: All  
Accepts Healthy Volunteers: No  


Inclusion Criteria:

  • Adults with stable antiretroviral therapy and negative for hepatitis A or B

Exclusion Criteria:
  • Prior hepatitis A or B

contacts and locations

Contacts and Locations

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Please refer to this study by its identifier: NCT00451984


Contact:   Henrik Nielsen, MD, DMSci +45-99326525


Department of Infectious Diseases, Aalborg Hospital Recruiting
Aalborg, Denmark, DK9000
Principal Investigator: Raquel M Iguacel, MD
Sub-Investigator: Henrik Nielsen, MD, DMSci
Department of Infectious Diseases, Skejby Hospital Not yet recruiting
Aarhus, Denmark, DK8200
Contact: Alex Laursen, MD, DMSci    +45-89495566
Principal Investigator: Ole Søgaard, MD

Sponsors and Collaborators

Aalborg University Hospital


Study Chair: Henrik Nielsen, MD, DMSci Aalborg Hospital, DK-9000 Aalborg, Denmark
More Information

More Information

Responsible Party: Aalborg University Hospital Identifier: NCT00451984   History of Changes  
Other Study ID Numbers: VN2005/32  
Study First Received: March 23, 2007  
Last Updated: October 31, 2007  

Keywords provided by Aalborg University Hospital:

treatment experienced

Additional relevant MeSH terms:
Hepatitis A
HIV Infections
Acquired Immunodeficiency Syndrome
Hepatitis B
Interleukin-2 processed this data on June 01, 2020
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