Ferumoxytol-enhanced Brain MRI in HIV-associated Neurocognitive Disorders
University of Hawaii
Oregon Health and Science University
Information provided by (Responsible Party)
Beau Nakamoto, University of Hawaii
First received: August 13, 2012
Last updated: August 15, 2012
Last Verified: August 2012
History of Changes
The purpose of this study is to describe the radiologic findings on brain MRI after ferumoxytol administration in HIV-infected patients with cognitive impairment.
Drug : Ferumoxytol
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
|Official Title:||Neuroimaging Correlates of Monocyte/Macrophage Infiltration in HIV-infected Individuals: A Cross-sectional Pilot Study Using IV Ferumoxytol|
Further study details as provided by Beau Nakamoto, University of Hawaii:
Primary Outcome Measures
Post-ferumoxytol enhancement on Brain MRI
[ Time Frame: 48 hour following administration of a dose of 4 mg/kg of feruomoxytol up to a maximum of 510 mg of elemental iron ]
The location and extent of ferumoxytol enhancement within the brain will be described.
[ Time Frame: 1 hour and 1 month following administration of a dose of 4 mg/kg of ferumxotyol up to a maximum of 510 mg of elemental iron ]
The rate of overall grade > 2 toxicities (categorized by the NIAID Division of AIDS adverse events table) during ferumoxytol infusion and 1 month post-ferumoxytol infusion will be assessed.
|Study Start Date:||July 2011|
|Study Completion Date:||June 2012|
|Primary Completion Date:||June 2012 (Final data collection date for primary outcome measure)|
Brain MRI will be performed before and 48 +/- 8 hours after ferumoxytol administration.
A dose of 4 mg/kg of ferumoxytol up to a maximum of 510 mg of elemental iron will be administered.
Other Name: FERAHEME
The continued existence of cognitive dysfunction in HIV infected individuals in the era of
effective antiretroviral therapy may be, in part, secondary to the failure of current
antiretroviral regimens to eradicate the pool of HIV-infected and activated monocytes within
the bloodstream. Trafficking of such HIV infected and activated blood monocytes into the
brain parenchyma is believed to introduce HIV into the brain and precipitate immune
activation and inflammation, ultimately leading to neuronal degeneration.
Ferumoxytol is an ultrasmall superparamagnetic iron-oxide (USPIO), which is FDA-approved for intravenous iron-replacement therapy in anemic patients with chronic kidney disease. The paramagnetic properties of ferumoxytol also allow it to be used as a MRI contrast agent. Ferumoxytol is avidly taken up by circulating monocytes and reactive astrocytes, microglia, and dendritic cells within the brain, making it potentially a novel biomarker for HIV-associated cognitive impairment given the role of monocytes in its pathogenesis.
This proposal intends to investigate the possible use of ferumoxytol (a new MRI contrast agent) as a biomarker for HIV-associated cognitive impairment and to assess the safety and tolerability of ferumoxytol in HIV-infected individuals.
Hypotheses to be tested:
- HIV-infected subjects with undetectable plasma HIV RNA levels and detectable levels of HIV DNA in CD14+ peripheral blood mononuclear cells (PBMCs) and impairment on neurocognitive testing will demonstrate ferumoxytol contrast enhancement in the perivascular regions of the brain consistent with monocyte/macrophage infiltration in these regions.
|Ages Eligible for Study:||19 Years and older|
|Sexes Eligible for Study:||All|
|Accepts Healthy Volunteers:||No|
- HIV-1 infection as documented by ELISA and confirmed by Western blot, HIV-1 culture, HIV-1 antigen, plasma HIV-1 RNA by RT-PCR or DNA at any time prior to study entry.
- Receipt of antiretroviral (ARV) medication uninterrupted for at least 6 months leading up to the screening period with demonstrated plasma HIV RNA < 48 copies/ml within the last 6 months.
- Willingness for both males and females of childbearing potential to utilize 2 effective contraception methods (2 separate forms, one of which must be an effective barrier method), be non-heterosexually active or have a an exclusive vasectomized partner from screening throughout the duration of the study treatment and for 30 days following the last dose of study drugs.
- Age >18 years.
- Ability and willingness to provide written informed consent
- HIV DNA > 10 copies/106 CD14+ PBMCs
- Mild or greater cognitive impairment as indicated by global NPZ8 z-score < -0.5 with a neurocognitive abnormality (defined as a z-score < -0.5) in at least one cognitive domain characteristic of HAD (i.e., executive function, psychomotor speed, memory).
- Requirement for acute therapy for other AIDS-defining illness or other serious medical illnesses (in the opinion of the site investigator) within 14 days prior to study entry.
- Known allergic or hypersensitivity reaction to FERAHEME, parental iron, parental dextran, parental iron-dextran, or parental iron-polysaccharide preparations
- Known history of an iron overload syndrome (e.g., hereditary hemochromatosis, porphyria cutanea tarda)
- Medical conditions (e.g., chronic hemolytic anemia) which requires frequent blood transfusions
- Taking oral iron supplementation
- Any factor that precludes MRI scan including presence of metal or exposure to metal work (e.g. metal grinder/worker) and claustrophobia
- Past or present HIV opportunistic infection of the brain, learning disability, head injury with prolonged loss of consciousness or cognitive sequelae, or other non-HIV risk factor that in the opinion of the principal investigator (PI) may impact cognitive performance.
- History of epilepsy requiring treatment with an antiepileptic
- Other chronic illnesses including insulin-dependent diabetes, autoimmune diseases, and endocrinopathies, except subjects on stable physiologic replacement therapy for low testosterone or thyroid levels
- Current active substance or alcohol dependence or positive urine toxicology screen.
- Pregnancy or breast-feeding, intent to become pregnant during the course of the study.
- Any condition which, in the opinion of the investigator, would compromise the subject's ability to participate in the study
- Aspartate aminotransferase (AST), alanine aminotransferase (ALT) greater than 2x upper limits of normal on pre-entry baseline laboratory safety assessment prior to study enrollment.
- Elevated iron levels on pre-entry baseline laboratory safety assessment prior to study enrollment.
- Hematocrit > 52% or Hemoglobin > 18 g/dL on pre-entry baseline laboratory safety
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01665846
Locations Show More
|United States, Hawaii|
|Hawaii Center for AIDS|
|Honolulu, Hawaii, United States, 96816|
Sponsors and CollaboratorsUniversity of Hawaii
Oregon Health and Science University
|Principal Investigator:||Beau K Nakamoto, MD, PhD||University of Hawaii, Hawaii Center for AIDS, John A Burns School of Medicine|
|Responsible Party:||Beau Nakamoto, Assistant Professor, University of Hawaii|
|ClinicalTrials.gov Identifier:||NCT01665846 History of Changes|
|Other Study ID Numbers:||H015|
|Study First Received:||August 13, 2012|
|Last Updated:||August 15, 2012|
Keywords provided by Beau Nakamoto, University of Hawaii:HIV associated neurocognitive disorders
Additional relevant MeSH terms:
AIDS Dementia Complex
ClinicalTrials.gov processed this data on October 19, 2017
This information is provided by ClinicalTrials.gov.