Metabolomics Fingerprinting and Metabolic Dynamics After HIV Infection
Verified April 2017 by Sichuan Academy of Medical Sciences
Sichuan Academy of Medical Sciences
Information provided by (Responsible Party)
Sichuan Academy of Medical Sciences
First received: April 5, 2013
Last updated: April 26, 2017
Last Verified: April 2017
History of Changes
The purpose of this plot study is to find out the relationship between metabolic changes and anti-retroviral therapy (ART), life style and clinical conditions of HIV-infected patients using nuclear magnetic resonance (NMR) based systems biology approach and metabolomics methodology.
Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Metabolic Fingerprintings and Metabolic Dynamics After HIV Infection:Impact of Metabolic Changes and Anti-Retroviral Therapy, Life Style and Clinical Conditions|
Further study details as provided by Sichuan Academy of Medical Sciences:
Primary Outcome Measures
- Dyslipidemia [ Time Frame: Dyslipidemia events from admission to discharge(Up to 6 months) ) ]
- Lipoatrophy [ Time Frame: Lipoarophy events from admission to discharge (up to 6 months) ]
Biospecimen Retention: Samples Without DNA
Plasma from peripheral blood
|Study Start Date:||March 2013|
|Estimated Study Completion Date:||March 2020|
|Estimated Primary Completion Date:||March 2019 (Final data collection date for primary outcome measure)|
100 confirmed HIV-1 infected patients who meet inclusion criteria.
Since the clinical application of anti-retroviral therapy (ART) in 1997, the life expectancy
of HIV infected patients has been prolonged greatly. However,side effects of ART including
metabolic abnormalities have become the main factors influencing patients' quality of life.
Among which the abnormal lipid metabolism plays an important role. Meanwhile, metabolic
conditions differ from patients applying to different combinations of ART drugs,life style
and clinical conditions.
Metabolomics can measure the dynamic metabolic responses of the body to stimuli or modifications. Using nuclear magnetic resonance (NMR) as tools can systematically analyse the process of lipid metabolism. Metabolomics fingerprinting can be defined as the complete complement of small molecule (< 1500 Da) metabolites found in a specific cell, body fluid, organ or organism.
Therefore, the study of the impact of metabolic changes and anti-retroviral therapy (ART), life style and clinical conditions is of importance in enhancing the adherence and improving the clinical outcomes of HIV infected patients.
|Ages Eligible for Study:||18 Years to 60 Years|
|Sexes Eligible for Study:||All|
|Accepts Healthy Volunteers:||Yes|
|Sampling Method:||Non-Probability Sample|
Study PopulationRecruit 100 HIV-infected individuals from community HIV Clinic and/or Transmitted Disease Hospital of Chengdu
- Clinical diagnosis of HIV infection
- Individual who is participating in other trial(s)
Contacts and LocationsChoosing to participate in a study is an important personal decision.Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01828268
|Contact: Hua JIANG, PhDfirstname.lastname@example.org|
|Contact: Bing CAI, Master||+86-28-88424391|
Locations Show More
|Sichuan Academy of Medical Sciences,Sichuan Provincial Hospital, Metabolomics and Mutidisciplinary Laboratory||Recruiting|
|Chengdu, Sichuan, China, 610101|
Contact: Hua JIANG, PhD  +86-28-88424391  email@example.com
Principal Investigator: Jin PENG, Master
Sponsors and CollaboratorsSichuan Academy of Medical Sciences
|Study Chair:||Hua JIANG, PhD||3Sichuan Academy of Medical Science, Sichuan Provincial People's Hospital, East Branch, Metabonomics and Multidisciplinary Laboratory|
|Principal Investigator:||Jin PENG, Master||3Sichuan Academy of Medical Science, Sichuan Provincial People's Hospital, East Branch, Metabonomics and Multidisciplinary Laboratory|
|Responsible Party:||Sichuan Academy of Medical Sciences|
|ClinicalTrials.gov Identifier:||NCT01828268 History of Changes|
|Other Study ID Numbers:||META-HA-001-2013|
|Study First Received:||April 5, 2013|
|Last Updated:||April 26, 2017|
Keywords provided by Sichuan Academy of Medical Sciences:HIV
Additional relevant MeSH terms:
Acquired Immunodeficiency Syndrome
ClinicalTrials.gov processed this data on February 23, 2018
This information is provided by ClinicalTrials.gov.