DidanosineBrand Name: Videx EC, Videx Other Names: ddI, ddl EC, delayed-release didanosine, dideoxyinosine, enteric-coated didanosine Drug Class: Nucleoside Reverse Transcriptase Inhibitors
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What are the most important things to know about didanosine?
Didanosine can cause serious, life-threatening side effects. These include swelling of the( ), a buildup of in the blood ( ), and problems.
Contact your health care provider right away if you have any of the following symptoms that could be signs of pancreatitis:
- Severe stomach pain
- Swelling of your stomach
Contact your health care provider right away if you have any of the following symptoms that could be signs of lactic acidosis:
- Feeling very weak or tired
- Unusual muscle pain
- Trouble breathing
- Stomach pain with nausea and vomiting
- Feeling cold, especially in your arms and legs
- Feeling dizzy or lightheaded
- Fast or irregular heartbeat
- Weight loss
Contact your health care provider right away if you have any of the following symptoms that could be signs of liver problems:
- Yellowing of your skin or the whites of your eyes ( )
- Dark-colored urine
- Light-colored stools
- Loss of appetite
- Pain, aching, or tenderness on the right side of your stomach
Didanosine should not be taken with stavudine (another HIV medicine; brand name: Zerit). Didanosine may interact with stavudine, which can cause serious, life-threatening side effects.
While taking didanosine, it is important to keep all of your appointments with your health care provider.
What is didanosine?
Didanosine is a prescription medicine approved by the U.S.(FDA) for the treatment of HIV in adults and children 2 weeks of age and older. Didanosine is always used in combination with other HIV medicines.
HIV medicines can’t cure HIV/AIDS, but taking HIV medicines every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV. If you are taking HIV medicines, don’t cut down on, skip, or stop taking them unless your health care provider tells you to.
What should I tell my health care provider before taking didanosine?
Before taking didanosine, tell your health care provider:
- If you are allergic to didanosine or any other medicines.
- If you have or have ever had problems with your pancreas, including pancreatitis.
- If you have or have ever had kidney problems.
- If you have or have ever had liver problems, including .
- If you have or have ever had numbness, tingling, or pain in your hands or feet ( ).
- If you are receiving dialysis.
- If you have any other medical conditions.
- If you drink alcoholic beverages. Do not drink alcohol while taking didanosine.
- If you take a medicine called stavudine (brand name: Zerit).
- If you are pregnant or plan to become pregnant. Whether didanosine can harm an unborn baby is unknown. Didanosine should be used during pregnancy only if the potential benefits outweigh the risks. Talk to your health care provider about the risks of taking didanosine during pregnancy.
- If you are breastfeeding or plan to breastfeed. Do not breastfeed if you have HIV or are taking didanosine.
- If you are using HIV and Birth Control infographic. -based birth control (such as pills, implants, or vaginal rings). For more information about using birth control and HIV medicines at the same time, view the
- About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Didanosine may affect the way other medicines or products work, and other medicines or products may affect how didanosine works. Taking didanosine together with certain medicines or products may cause serious, life-threatening side effects.
How should I take didanosine?
Didanosine comes in a powder that is mixed with water by a pharmacist to create an oral solution. The powder for oral solution can be used in adults and in children 2 weeks of age and older. The powder for oral solution comes in two strengths, both under the brand name Videx:
- 4-oz glass bottle containing 2 g of didanosine
- 8-oz glass bottle containing 4 g of didanosine
Didanosine also comes in capsule form for use in adults and children 6 years of age or older who can safely swallow capsules and who weigh at least 44 lb (20 kg). The capsules come in four strengths, all under the brand name Videx EC:
- 125-mg, 200-mg, 250-mg, and 400-mg delayed-release capsules, containing beadlets. The coating prevents stomach acids from breaking down the didanosine beadlets before the HIV medicine is absorbed in the small intestine.
Take didanosine according to your health care provider’s instructions.
Both didanosine capsules and didanosine oral solution should be taken on an empty stomach. Do not take didanosine with food. Take didanosine oral solution at least 30 minutes before or 2 hours after you eat. Swallow the didanosine capsule whole; do not break, crush, dissolve, or chew it.
Some medicines should not be taken at the same time of day that you take didanosine. Talk to your health care provider about other medicines that you take.
Always take didanosine in combination with other HIV medicines.
If you take too much didanosine, contact your health care provider or local poison control center (1-800-222-1222) right away, or go to the nearest hospital emergency room.
For more information on how to take didanosine, see the FDA drug labels.
What should I do if I forget a dose?
If you miss a
What side effects can didanosine cause?
Didanosine may cause side effects. Many side effects from HIV medicines, such as nausea or occasional dizziness, are manageable. See the AIDSinfo fact sheet on HIV Medicines and Side Effects for more information.
Some side effects of didanosine can be serious. Serious side effects of didanosine include swelling of the pancreas (pancreatitis), a buildup of lactic acid in the blood (lactic acidosis), and liver problems. (See section above: What are the most important things to know about didanosine?)
Other possible side effects of didanosine include:
- Damage to the nerves outside the brain and spinal cord (peripheral ). Symptoms include numbness, tingling, or pain in your hands or feet.
- Vision changes, such as blurred vision.
- Changes in your (called or IRIS). IRIS is a condition that sometimes occurs when the immune system begins to recover after treatment with an HIV medicine. As the immune system gets stronger, it may have an increased response to a previously hidden infection.
- Loss of body fat (
Tell your health care provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of didanosine. To learn more about possible side effects of didanosine, read the drug label oror talk to your health care provider or pharmacist.
You can also report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online.
How should didanosine be stored?
- Store didanosine capsules in a tightly closed container at 59°F to 86°F (15°C to 30°C).
- Store bottles of didanosine powder at 59°F to 86°F (15°C to 30°C). The oral solution can be stored for up to 30 days in a tightly closed container in a refrigerator at 36°F to 46°F (2°C to 8°C). Any solution left after 30 days should be thrown away.
- Keep didanosine in the container that it came in and keep the container tightly closed.
- Do not use didanosine if the original seal over the container opening is broken or missing.
- Throw away didanosine that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine.
- Keep didanosine and all medicines out of reach of children.
Where can I find more information about didanosine?
More information about didanosine is available:
Main number: 800-332-2056
Patient assistance: 888-281-8981
Last Reviewed: December 2, 2019