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AIDSinfo Drug Database

AIDSinfo Drug Database

Drugs by class



Delavirdine  Audio icon

Brand Name: Rescriptor
Other Names: DLV, delavirdine mesylate
Drug Class: Non-nucleoside Reverse Transcriptase Inhibitors

Drug Image:
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Rescriptor 100mg
Chemical Image:
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delavirdine mesylate
delavirdine mesylate
Molecular Weight: 552.6738


Delavirdine can cause serious, life-threatening side effects. This includes severe skin rash.

If you have a severe skin rash or have any of the following symptoms along with a skin rash, stop taking delavirdine and contact your health care provider right away:

  • Fever.
  • Blistering.
  • Sores in your mouth.
  • Redness or swelling of your eyes.
  • Muscle or joint aches.

Taking certain medicines with delavirdine may cause serious, life-threatening side effects. Tell your health care provider about all medicines you are taking or planning to take before you take delavirdine.

While taking delavirdine, it is important to keep all of your appointments with your health care provider.

What is delavirdine?

Delavirdine is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults. Delavirdine is always used in combination with other HIV medicines.

Delavirdine belongs to a class (group) of HIV drugs called non-nucleoside reverse transcriptase inhibitors (NNRTIs). NNRTIs attach to and block an HIV enzyme called reverse transcriptase. (An enzyme is a protein that starts or increases the speed of a chemical reaction.) By blocking reverse transcriptase, NNRTIs prevent HIV from multiplying and can reduce the amount of HIV in the body.

HIV medicines can’t cure HIV/AIDS, but taking a combination of HIV medicines (called an HIV regimen) every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV transmission.

What should I tell my health care provider before taking delavirdine?

Before taking delavirdine, tell your health care provider:

  • If you are allergic to delavirdine or any other medicines.
  • If you have liver or kidney disease.
  • If you have any other medical conditions.
  • If you are pregnant or plan to become pregnant. Whether delavirdine can harm an unborn baby is unknown. Delavirdine should be used during pregnancy only if the potential benefits outweigh the risks.Talk to your health care provider about possible risks with taking delavirdine when pregnant.
  • If you are breastfeeding or plan to breastfeed. Do not breastfeed if you are infected with HIV or are taking delavirdine.
  • If you are using hormone-based birth control (such as pills, injections, or implants).
  • About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Delavirdine may affect the way other medicines or products work, and other medicines or products may affect how delavirdine works. Taking delavirdine together with certain medicines or products may cause serious/life-threatening side effects.

How should I take delavirdine?

Delavirdine comes in tablet form in two strengths:

  • 100-mg tablets (brand name: Rescriptor).
  • 200-mg tablets.

Take delavirdine according to your health care provider’s instructions.

You may take delavirdine with or without food. Taking delavirdine on a regular schedule along with activities you do every day, such as getting up in the morning, brushing your teeth, eating lunch, coming home from work in the evening, or watching a favorite TV show, will make it easier to remember to take every dose.

If you are taking both delavirdine and antacids, take them at least 1 hour apart. If your health care provider has told you that you don’t have enough stomach acid, take delavirdine with orange or cranberry juice.

If you have trouble swallowing tablets, the 100-mg delavirdine tablets may be dissolved in water. Add four tablets to at least 3 ounces of water. Allow the tablets to sit in the water for a few minutes. Stir the water until the tablets have dissolved and then drink the delavirdine-water mixture right away. Rinse the glass and swallow the rinse to make sure that you get all the medicine. Delavirdine 200-mg tablets cannot be dissolved in water and must be swallowed whole.

Always take delavirdine in combination with other HIV medicines.

If you take too much delavirdine, contact your health care provider or local poison control center (1-800-222-1222) right awayor go to the nearest hospital emergency room.

For more information on how to take delavirdine, see the FDA drug label from DailyMed. (DailyMed is a federal website that includes the most recent drug labels submitted to FDA.) 

What should I do if I forget a dose?

If you miss a dose of delavirdine, take the missed dose as soon as you remember it. But if it is almost time for your next dose, skip the missed dose and just take your next dose at the regular time. Do not take two doses at the same time to make up for a missed dose.

What side effects can delavirdine cause?

Delavirdine can cause serious, life-threatening side effects. This includes severe skin rash. (See the WARNING above.)

Other possible side effects of delavirdine include:

  • Changes in body fat (including gain or loss of fat).
  • Immune reconstitution inflammatory syndrome (IRIS), a condition that sometimes occurs when the immune system begins to recover after treatment with an HIV medicine. As the immune system gets stronger, it may have an increased response to a previously hidden infection.
  • Headache, nausea, diarrhea, and tiredness.

Tell your health care provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of delavirdine. To learn more about possible side effects of delavirdine, read the drug label or package insert or talk to your health care provider or pharmacist.

The AIDSinfo fact sheet on HIV Medicines and Side Effects also includes information that may apply to delavirdine.

You can also report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online at

How should delavirdine be stored?

  • Store delavirdine at room temperature, 68°F to 77°F (20°C to 25°C).
  • Keep delavirdine in the bottle that it came in and keep the bottle tightly closed. If the bottle has a small packet of drying agent (called a desiccant), do not remove it. The dessicant protects the medicine from moisture.
  • Do not use delavirdine if the original seal over the bottle opening is broken or missing.
  • Keep the bottle away from heat and moisture (don’t store it in the bathroom).
  • Throw away delavirdine that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicines.  
  • Keep delavirdine and all medicines out of reach of children.

Where can I find more information about delavirdine?

More information about delavirdine is available:

Manufacturer Information

ViiV Healthcare

The above Patient Version drug summary is based on the following FDA label(s): Tablet.

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