Indinavir can cause serious, life-threatening side effects. These include kidney problems, rapid breakdown of red blood cells (hemolytic anemia), and possibly liver problems.
Contact your health care provider right away if you have any of the following symptoms:
While taking indinavir, it is important to keep all of your appointments with your health care provider.
Indinavir is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults. Indinavir is always used in combination with other HIV medicines.
Indinavir belongs to a class (group) of HIV drugs called protease inhibitors (PIs). PIs block an HIV enzyme called protease. (An enzyme is a protein that starts or increases the speed of a chemical reaction.) By blocking protease, PIs prevent HIV from multiplying and can reduce the amount of HIV in the body.Indinavir is a type of anti-HIV medicine called a protease inhibitor (PI). Indinavir works by blocking protease, an HIV enzyme. This prevents HIV from replicating and lowers the amount of HIV in the blood.
HIV medicines can’t cure HIV/AIDS, but taking a combination of HIV medicines (called an HIV treatment regimen) every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV transmission. If you are taking HIV medicines, including indinavir, don’t cut down on, skip, or stop taking them unless your health care provider tells you to.
Before taking indinavir, tell your health care provider:
Indinavir comes in capsule form in two different strengths, under the brand name Crixivan:
Take indinavir according to your health care provider’s instructions.
Take indinavir capsules every 8 hours around the clock, every day. Take indinavir with water (or other beverage such as skim or nonfat milk, juice, coffee, or tea) at least 1 hour before or 2 hours after a meal. Or you can take indinavir with a light meal that is low in calories, fat, and protein. Drink at least six 8-ounce glasses of liquids (preferably water) throughout the day to reduce the risk of kidney stones.
Always take indinavir in combination with other HIV medicines.
If you take too much indinavir, contact your health care provider local or poison control center (1-800-222-1222) right away, or go to the nearest hospital emergency room right away.
For more information on how to take indinavir, see the FDA drug label from DailyMed. (DailyMed is a federal website that includes the most recent drug labels submitted to FDA.) Toward the end of the label is patient information for people taking indinavir.
If you miss a dose of indinavir by more than 2 hours, wait and then take the next dose at the regularly scheduled time. If you miss a dose by less than 2 hours, take the missed dose immediately. Then take your next dose at the regularly scheduled time. Do not take more or less than your prescribed dose of indinavir at any one time.
Indinavir can cause serious, life-threatening side effects. These include kidney problems, rapid breakdown of red blood cells (hemolytic anemia), and possibly liver problems. (See the WARNING above.)
Other possible side effects of indinavir include:
Tell your health care provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of indinavir. To learn more about possible side effects of indinavir, read the drug label or package insert or talk to your health care provider or pharmacist.
The AIDSinfo fact sheet on HIV Medicines and Side Effects also includes information that may apply to indinavir.You can also report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online at https://www.accessdata.fda.gov/scripts/medwatch/.
More information about indinavir is available:
Merck & Co., Inc.
Last Reviewed: May 21, 2015