Enfuvirtide causes injection site reactions. Almost all people get injection site reactions with enfuvirtide, which usually are mild to moderate but occasionally can be severe. Reactions on the skin where enfuvirtide is injected include:
Contact your health care provider right away if you have signs of infection at an injection site (oozing, increasing heat, swelling, redness, or pain).
Enfuvirtide can cause serious side effects. These include severe allergic reaction and possibly pneumonia.
Contact your health care provider right away if you have any of the following symptoms that could be signs of a severe allergic reaction:
Contact your health care provider right away if you have any of the following symptoms that could be signs of pneumonia:
While taking enfuvirtide, it is important to keep all of your appointments with your health care provider.
Enfuvirtide is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults and children 6 years of age and older. Enfuvirtide is for people who have not responded well enough to treatment with other HIV medicines. Enfuvirtide is always used in combination with other HIV medicines.
Enfuvirtide belongs to a class (group) of HIV drugs called entry and fusion inhibitors. Entry and fusion inhibitors block HIV from getting into and infecting certain cells of the immune system. This prevents HIV from multiplying and can reduce the amount of HIV in the body.
Before taking enfuvirtide, tell your health care provider:
Enfuvirtide comes in powder form and is given as an injection (a shot). Each vial contains 108 mg of enfuvirtide powder. The enfuvirtide powder and everything needed to give the injection come in a convenience kit. The kit includes:
Take enfuvirtide according to your health care provider’s instructions. You or your caregiver should be trained by a health care provider on how to mix and inject enfuvirtide before injecting it. If you are having a hard time mixing or injecting enfuvirtide, contact your health care provider.
Enfuvirtide should be injected under the skin in the upper arm, upper leg, or stomach two times a day. Do not inject enfuvirtide in the same area as you did the time before. Do not inject enfuvirtide into the following areas: near the elbow, knee, groin, or lower or inner buttocks; directly over a blood vessel; around the belly button, scar tissue, a bruise, a mole, a surgical scar, a tattoo, or a burn site; or where there is an injection site reaction.
If enfuvirtide is foamy or jelled, allow more time for it to dissolve. Do not inject enfuvirtide if you see particles floating in the vial after it has been mixed. Enfuvirtide can be taken with or without food. Do not swallow enfuvirtide; it must be injected.
After injecting enfuvirtide, place used syringes in a special disposal container (called a sharps container). Do not place used syringes in a trash can.
Always take enfuvirtide in combination with other HIV medicines.
If you take too much enfuvirtide, contact your health care provider or local poison control center (1-800-222-1222) right away, or go to the nearest hospital emergency room.
For more information on how to take enfuvirtide, see the FDA drug label from DailyMed. (DailyMed is a federal website that includes the most recent drug labels submitted to FDA.)
Take the missed dose as soon as you remember it. But if it is almost time for your next dose, skip the missed dose and just take your next dose at the regular time. Do not take two doses at the same time to make up for a missed dose.
Enfuvirtide can cause serious side effects. These include severe allergic reaction, severe or infected injection sites, and possibly pneumonia. (See the WARNING above.)
Other possible side effects of enfuvirtide include:
Tell your health care provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of enfuvirtide. To learn more about possible side effects of enfuvirtide, read the drug label or package insert or talk to your health care provider or pharmacist.
The AIDSinfo fact sheet on HIV Medicines and Side Effects also includes information that may apply to enfuvirtide.
You can also report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online at https://www.accessdata.fda.gov/scripts/medwatch/.
More information about enfuvirtide is available:
Hoffman-La Roche; Genentech
Last Reviewed: October 15, 2014