Kaletra can cause serious, life-threatening side effects. These include liver problems, pancreatitis (inflammation of the pancreas), heart rhythm problems, severe allergic reactions, and life-threatening drug interactions.
Contact your health care provider right away if you have any of the following symptoms that could be signs of liver problems:
Contact your health care provider right away if you have any of the following symptoms that could be signs of pancreatitis:
Contact your health care provider right away if you have any of the following symptoms that could be signs of heart rhythm problems:
Contact your health care provider right away if you develop a skin rash. This could be a sign of a severe allergic reaction.
Babies taking Kaletra oral solution may have side effects. (An oral solution is a mixture of a medicine and a liquid that can be taken by mouth.) Kaletra oral solution contains alcohol and propylene glycol. Contact your health care provider right away if your baby appears too sleepy or his/her breathing has changed.
Taking Kaletra with certain other medicines may result in serious, life-threatening side effects.
While taking Kaletra, it is important to keep all of your appointments with your health care provider.
Kaletra is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults and children 14 days of age and older. Kaletra is always used in combination with other HIV medicines.
Kaletra contains the following two different medicines combined in one pill:
PIs block an HIV enzyme called protease. (An enzyme is a protein that starts or increases the speed of a chemical reaction.) By blocking protease, the two drugs in combination prevent HIV from multiplying and can reduce the amount of HIV in the body.
HIV medicines can’t cure HIV/AIDS, but taking a combination of HIV medicines (called an HIV regimen) every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV transmission. If you are taking HIV medicines, including Kaletra, don’t cut down on, skip, or stop taking them unless your health care provider tells you to.
Before taking Kaletra, tell your health care provider:
Kaletra comes in the following forms and strengths:
Take Kaletra according to your health care provider’s instructions. If your child is prescribed Kaletra, tell your doctor if your child’s weight changes.
Kaletra tablets can be taken with or without food. Swallow the tablets whole. Do not chew, break, or crush the tablets.
Take Kaletra oral solution with food. Pregnant women should not take Kaletra oral solution.
If you take too much Kaletra, contact your health care provider or local poison control center (1-800-222-1222) right away, or go to the nearest hospital emergency room.
For more information on how to take Kaletra, see the FDA drug label from DailyMed. (DailyMed is a federal website that includes the most recent drug labels submitted to FDA.)
If you miss a dose of Kaletra, take the missed dose as soon as you remember it. But if it is almost time for your next dose, skip the missed dose and just take your next dose at the regular time. Do not take two doses at the same time to make up for a missed dose.
Kaletra may cause side effects. Most side effects from Kaletra are manageable, but a few can be serious. Serious side effects of Kaletra include liver problems, pancreatitis (inflammation of the pancreas), heart rhythm problems, severe allergic reactions, and life-threatening drug interactions. (See the WARNING above.)
Other possible side effects of Kaletra include:
Tell your health care provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of Kaletra. To learn more about possible side effects of Kaletra, read the drug label or package insert or talk to your health care provider or pharmacist.
The AIDSinfo fact sheet on HIV Medicines and Side Effects also includes information that may apply to Kaletra.
You can report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online at https://www.accessdata.fda.gov/scripts/medwatch/.
More information about Kaletra is available:
Main number: 800-633-9110
Patient assistance: 800-222-6885
Last Reviewed: September 6, 2016