Abacavir / Lamivudine / ZidovudineBrand Name: Trizivir Other Names: ABC / 3TC / ZDV, abacavir sulfate / lamivudine / zidovudine Drug Class: Combination Drugs
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What are the most important things to know about Trizivir?
Trizivir can cause serious, life-threatening side effects. These include allergic reactions, a buildup ofin the blood ( ), problems, muscle pain or weakness ( ), and blood disorders such as extremely reduced numbers of red blood cells (severe ) or reduced numbers of white blood cells ( ).
Trizivir contains abacavir, an HIV medicine. People who take abacavir-containing products may have a serious allergic reaction ( reaction) that can cause death. Your risk of this allergic reaction is much higher if you have a variation called HLA-B*5701. Your health care provider can determine if you have this gene variation with a blood test. If you get a symptom from two or more of the following groups while taking Trizivir, contact your health care provider right away to find out if you should stop taking Trizivir.
- Group 1 Symptoms: Fever
- Group 2 Symptoms: Rash
- Group 3 Symptoms: Nausea, vomiting, diarrhea, abdominal (stomach area) pain
- Group 4 Symptoms: General ill feeling, extreme tiredness, or achiness
- Group 5 Symptoms: Shortness of breath, cough, sore throat
Your pharmacist will give you a Medication Guide and Warning Card with a list of these symptoms. Carry this Warning Card with you at all times.
If you stop Trizivir because of an allergic reaction, never take Trizivir or any other abacavir-containing medicine again. If you take Trizivir or any other abacavir-containing medicine again after you have had an allergic reaction, within hours you may get life-threatening symptoms that may include very low blood pressure or lead to death. If you stop Trizivir for any other reason, even for a few days, and you are not allergic to Trizivir, talk with your health care provider before taking it again. Taking Trizivir again can cause a serious allergic or life-threatening reaction, even if you never had an allergic reaction to Trizivir before. If your health care provider tells you that you can take Trizivir again, start taking it when you are around medical help or people who can call a health care provider if you need one.
Contact your health care provider right away if you have any of the following symptoms that could be signs of lactic acidosis:
- Weakness or tiredness
- Unusual muscle pain
- Trouble breathing
- Stomach pain with nausea and vomiting
- Feeling cold, especially in your arms and legs
- Dizziness or lightheadedness
- Fast or irregular heartbeat
Contact your health care provider right away if you have any of the following symptoms that could be signs of serious liver problems:
- Yellowing of your skin or the whites of your eyes ( )
- Dark-colored urine
- Light-colored bowel movements
- Loss of appetite for several days or longer
- Pain, aching, or tenderness on your right side in the stomach area (abdominal pain)
Contact your health care provider right away if you have muscle pain or weakness.
Trizivir can cause blood disorders such as extremely reduced numbers of red blood cells (severe anemia) or reduced numbers of white blood cells (neutropenia). Your health care provider should check your blood cell counts regularly during treatment with Trizivir.
If you have both HIV and(HBV) and take Trizivir, your HBV may get worse (flare up) if you stop taking Trizivir. The B can also change (mutate) during your treatment with Trizivir and become harder to treat (resistant).Do not stop taking Trizivir without first talking to your health care provider. If your health care provider tells you to stop Trizivir, you will be monitored closely for several months to check your HBV infection.
Worsening of liver disease (sometimes resulting in death) has occurred in people with both HIV and ribavirin. If you are taking Trizivir as well as interferon with or without ribavirin, tell your health care provider if you have any new symptoms.(HCV) who were taking HIV medicines and also being treated for HCV infection with with or without
While taking Trizivir, it is important to keep all of your appointments with your health care provider.
What is Trizivir?
Trizivir is a prescription medicine approved by the U.S.(FDA) for the treatment of HIV infection in adults, adolescents and children who weigh at least 88 lb (40 kg). Trizivir can be used alone as a complete HIV or with other HIV medicines.
HIV medicines can’t cure HIV/AIDS, but taking HIV medicines every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV. If you are taking HIV medicines, don’t cut down on, skip, or stop taking them unless your health care provider tells you to.
What should I tell my health care provider before taking Trizivir?
Before taking Trizivir, tell your health care provider:
- If you are allergic to any of the HIV medicines in Trizivir (abacavir, lamivudine, or zidovudine) or any other medicines.
- If you have been tested and know whether you have a particular gene variation called HLA-B*5701.
- If you have or have ever had liver problems, including hepatitis B virus infection (HBV) or hepatitis C virus infection (HCV).
- If you have kidney problems.
- If you have low blood cell counts, which could be a sign of problems.
- If you have heart problems, smoke, or have diseases that increase your risk of heart disease, such as high blood pressure, high , or .
- If you have any other medical conditions.
- If you drink alcohol or take medicines that contain alcohol.
- If you are pregnant or plan to become pregnant. Talk to your health care provider about the risks and benefits of taking Trizivir during pregnancy.
- If you are breastfeeding or plan to breastfeed. Do not breastfeed if you have HIV or are taking Trizivir.
- If you are using HIV and Birth Control infographic. -based birth control (such as pills, implants, or vaginal rings). For more information about using birth control and HIV medicines at the same time, view the
- About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take, especially interferon and ribavirin. Trizivir may affect the way other medicines or products work, and other medicines or products may affect how Trizivir works. Taking Trizivir together with certain medicines or products may cause serious, life-threatening side effects.
How should I take Trizivir?
Trizivir comes in tablet form. Each tablet contains:
- 300 mg abacavir (brand name: Ziagen)
- 150 mg lamivudine (brand name: Epivir)
- 300 mg zidovudine (brand name: Retrovir)
Take Trizivir according to your health care provider’s instructions.
Take Trizivir by mouth, with or without food.
If you take too much Trizivir, contact your health care provider or local poison control center (1-800-222-1222) right away, or go to the nearest hospital emergency room.
For more information on how to take Trizivir, see the FDA drug label.
What should I do if I forget a dose?
If you miss aof Trizivir, take the missed dose as soon as you remember it. But if it is almost time for your next dose, skip the missed dose and just take your next dose at the regular time. Do not take two doses at the same time to make up for a missed dose.
What side effects can Trizivir cause?
Trizivir may cause side effects. Many side effects from HIV medicines, such as nausea or occasional dizziness, are manageable. See the AIDSinfo fact sheet on HIV Medicines and Side Effects for more information.
Some side effects of Trizivir can be serious. Serious side effects of Trizivir include allergic reactions, a buildup of lactic acid in the blood (lactic acidosis), liver problems, muscle pain or weakness (myopathy), and blood disorders such as an extremely reduced numbers of red blood cells (severe anemia) or reduced numbers of white blood cells (neutropenia). (See section above: What are the most important things to know about Trizivir?)Other possible side effects of Trizivir include:
- Changes in your (called or IRIS). IRIS is a condition that sometimes occurs when the immune system begins to recover after treatment with an HIV medicine. As the immune system gets stronger, it may have an increased response to a previously hidden infection.
- Loss of body fat ( ).
- Increased risk of heart attack ( ).
Tell your health care provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of Trizivir. To learn more about possible side effects of Trizivir, read the drug label oror talk to your health care provider or pharmacist.
You can report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online.
How should Trizivir be stored?
- Store Trizivir at 59°F to 86°F (15°C to 30°C).
- Keep Trizivir in the container that it came in and keep the container tightly closed.
- Do not use Trizivir if the original seal over the container opening is broken or missing.
- Throw away Trizivir that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine.
- Keep Trizivir and all medicines out of reach of children.
Where can I find more information about Trizivir?
More information about Trizivir is available:
Main number: 877-844-8872
Patient assistance (ViiV Connect): 844-588-3288
The above Patient Version drug summary is based on the following FDA label(s): Tablet (film coated).
Last Reviewed: March 20, 2020