Tipranavir can cause serious, life-threatening side effects. These include liver problems, severe rash, and bleeding in the brain.
Stop taking tipranavir (and ritonavir, the HIV medicine always used with tipranavir) and contact your health care provider right away if you have any of the following symptoms that could be signs of liver problems:
Stop taking tipranavir and contact your health care provider right away if you develop a rash and one or more of the following symptoms:
Report any unusual or unexplained bleeding to your health care provider.
While taking tipranavir, it is important to keep all of your appointments with your health care provider.
Tipranavir is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults and children 2 years of age and older. Tipranavir is always used with the HIV medicine ritonavir (brand name: Norvir) and at least two other HIV medicines.
Tipranavir belongs to a class (group) of HIV drugs called protease inhibitors (PIs). PIs block an HIV enzyme called protease. (An enzyme is a protein that starts or increases the speed of a chemical reaction.) By blocking protease, PIs prevent HIV from multiplying and can reduce the amount of HIV in the body.
Tipranavir should be used only in people who have taken HIV medicines before and whose HIV is resistant to more than one PI.
HIV medicines can’t cure HIV/AIDS, but taking a combination of HIV medicines (called an HIV regimen) every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV transmission.
Before taking tipranavir, tell your health care provider:
Tipranavir comes in the following forms and strengths:
Take tipranavir according to your health care provider’s instructions.
Tipranavir capsules should be swallowed whole. Do not chew the capsules.
Tipranavir is always used with the HIV medicine ritonavir (brand name: Norvir) and at least two other HIV medicines. Take tipranavir and ritonavir at the same time. If you are taking tipranavir with ritonavir capsules or oral solution, the medicines can be taken with or without meals. If you are taking tipranavir with ritonavir tablets, the medicines must be taken only with meals.
The oral solution of tipranavir contains vitamin E. If you are taking the oral solution, don’t take additional vitamin E other than that contained in a standard multivitamin.
If you take too much tipranavir, contact your health care provider or local poison control center (1-800-222-1222) right away, or go to the nearest hospital emergency room.
Take the missed dose of tipranavir, together with ritonavir, as soon as you remember it. But if it is almost time for your next dose, skip the missed dose and just take your next dose at the regular time. Do not take two doses at the same time to make up for a missed dose.
Tipranavir can cause serious, life-threatening side effects. These include liver problems, severe rash, and bleeding in the brain. (See the WARNING above.)
Other possible side effects of tipranavir include:
Tell your health care provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of tipranavir. To learn more about possible side effects of tipranavir, read the drug label or package insert or talk to your health care provider or pharmacist.
The AIDSinfo fact sheet on HIV Medicines and Side Effects also includes information that may apply to tipranavir.
You can also report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online at https://www.accessdata.fda.gov/scripts/medwatch/.
More information about tipranavir is available:
Last Reviewed: February 5, 2015
Last Updated: February 5, 2015