Efavirenz / Emtricitabine / Tenofovir Disoproxil FumarateBrand Name: Atripla Other Names: EFV / FTC / TDF, efavirenz / emtricitabine / tenofovir DF Drug Class: Combination Drugs
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What are the most important things to know about Atripla?
Atripla can cause serious, life-threatening side effects. These include a buildup ofContact your health care provider right away if you have any of the following symptoms that could be signs of lactic acidosis: in the blood ( ) and problems.
- Weakness or tiredness
- Unusual muscle pain
- Shortness of breath or rapid breathing
- Stomach pain with nausea and vomiting
- Feeling cold or having blue hands and feet
- Dizziness or lightheadedness
- Fast or abnormal heartbeat
- Yellowing of your skin or the whites of your eyes ( )
- Dark-colored urine
- Light-colored bowel movements
- Loss of appetite for several days or longer
- Pain in your stomach area (abdominal pain)
While taking Atripla, it is important to keep all of your appointments with your health care provider.
What is Atripla?
Atripla is a prescription medicine approved by the U.S.(FDA) for the treatment of HIV in adults and children who weigh at least 88 lb (40 kg). Atripla can be used alone as a complete or with other HIV medicines.
Atripla contains the following three different HIV medicines combined in one tablet:
- Efavirenz – an HIV medicine called a (NNRTI)
- Emtricitabine – an HIV medicine called a (NRTI)
- Tenofovir disoproxil fumarate – another HIV medicine (also an NRTI)
Both NNRTIs and NRTIs block an HIVcalled . By blocking reverse transcriptase, the drugs in Atripla prevent HIV from multiplying and can reduce the amount of HIV in the body.
HIV medicines can’t cure HIV/AIDS, but taking a combination of HIV medicines (called an HIV treatment regimen) every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV. If you are taking HIV medicines, including Atripla (alone or with other HIV medicines), don’t cut down on, skip, or stop taking them unless your health care provider tells you to.
What should I tell my health care provider before taking Atripla?
Before taking Atripla, tell your health care provider:
- If you are allergic to any of the HIV medicines in Atripla (efavirenz, emtricitabine, or tenofovir disoproxil fumarate) or any other medicines.
- If you have liver problems, including B infection (HBV) or (HCV).
- If you have heart problems.
- If you have or have had mental problems.
- If you have a history of drug or alcohol abuse.
- If you have nervous system problems.
- If you have kidney problems or receive kidney dialysis treatment.
- If you have bone problems.
- If you have had seizures or are taking medicine used to treat seizures.
- If you have any other medical conditions.
- If you are pregnant or plan to become pregnant. Women should not become pregnant while taking Atripla and for 12 weeks after stopping it. Serious birth defects have been seen in the babies of animals and women treated with efavirenz (one of the medicines in Atripla) during pregnancy. Whether efavirenz caused the birth defects is unknown. Talk to your health care provider about how to continue your HIV treatment when pregnant.
- If you are breastfeeding or plan to breastfeed. Do not breastfeed if you have HIV or are taking Atripla.
- If you are using HIV and Birth Control infographic. -based birth control (such as pills, implants, or vaginal rings). Atripla may make these forms of birth control less effective. Women who are able to become pregnant should use two effective forms of birth control while taking Atripla and for 12 weeks after stopping treatment with Atripla. A barrier form of birth control, such as a or diaphragm, should be used along with another type of birth control. Your health care provider can help you decide how to adjust your birth control while you are taking Atripla. For more information about using birth control and HIV medicines at the same time, view the
- About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Atripla may affect the way other medicines or products work, and other medicines or products may affect how Atripla works. Taking Atripla together with certain medicines or products may cause serious side effects.
How should I take Atripla?
Atripla comes in tablet form. Each tablet contains:
- 600 mg efavirenz (brand name: Sustiva)
- 200 mg emtricitabine (brand name: Emtriva)
- 300 mg tenofovir disoproxil fumarate (brand name: Viread)
Take Atripla according to your health care provider’s instructions.
Take Atripla on an empty stomach, preferably at bedtime.
If you take too much Atripla, contact your health care provider or local poison control center (1-800-222-1222) right away, or go to the nearest hospital emergency room.
For more information on how to take Atripla, see the FDA drug label.
What should I do if I forget a dose?
If you miss aof Atripla, take the missed dose as soon as you remember it. But if it is almost time for your next dose, skip the missed dose and just take your next dose at the regular time. Do not take two doses at the same time to make up for a missed dose.
What side effects can Atripla cause?
Atripla may cause side effects. Many side effects from HIV medicines, such as nausea or occasional dizziness, are manageable. See the AIDSinfo fact sheet on HIV Medicines and Side Effects for more information.
Some side effects of Atripla can be serious. Serious side effects of Atripla include a buildup of lactic acid in the blood (lactic acidosis) and liver problems. (See section above: What are the most important things to know about Atripla?)Other possible side effects of Atripla include:
- Rash. A rash can be serious. Contact your health care provider right away if you develop a rash.
- Serious mental health problems, including severe , suicidal thoughts, or delusions.
- Nervous system problems. These may become more severe if you drink alcohol or take mood altering (street) drugs while taking Atripla.
- New or worsening kidney problems, including kidney failure.
- Bone problems (bone pain, softening, or thinning [ ]).
- Changes in your (called or IRIS). IRIS is a condition that sometimes occurs when the immune system begins to recover after treatment with an HIV medicine. As the immune system gets stronger, it may have an increased response to a previously hidden infection.
- Changes in body fat ( ).
Tell your health care provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of Atripla. To learn more about possible side effects of Atripla, read the drug label oror talk to your health care provider or pharmacist.
You can also report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online.
How should Atripla be stored?
- Store Atripla at room temperature, 68°F to 77°F (20°C to 25°C).
- Keep Atripla in the container that it came in and keep the container tightly closed. If the container has a small packet of drying agent (called a desiccant), do not remove it. The desiccant protects the medicine from moisture.
- Do not use Atripla if the original seal over the container opening is broken or missing.
- Throw away Atripla that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of medicine.
- Keep Atripla and all medicines out of reach of children.
Where can I find more information about Atripla?
More information about Atripla is available:
Gilead Sciences, Inc.
Main number: 800-445-3235
Patient assistance: 800-226-2056
The above Patient Version drug summary is based on the following FDA label(s): Tablet (film coated).
Last Reviewed: July 18, 2019