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AIDSinfo Drug Database

AIDSinfo Drug Database

Drugs by class

FDA-approved

Investigational

Rilpivirine  Audio icon

Brand Name: Edurant
Other Names: RPV, rilpivirine hydrochloride
Drug Class: Non-nucleoside Reverse Transcriptase Inhibitors
Approved Use: Treatment of HIV Infection
Drug Image:
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Rilpivirine
Chemical Image:
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rilpivirine hydrochloride
rilpivirine hydrochloride
Molecular Weight: 402.8871

WARNING:

Rilpivirine can cause serious, life-threatening side effects. These include depression, mood changes, and liver problems.

Contact your health care provider right away if you have any of the following symptoms of depression or mood changes:

  • Feeling sad or hopeless.
  • Feeling anxious or restless.
  • Having thoughts of hurting yourself (suicide) or have tried to hurt yourself.

Some people taking rilpivirine have had liver problems. People with a history of hepatitis B virus (HBV) or hepatitis C virus (HCV) infection or who have elevated results on liver function tests may have an increased risk of developing new or worsening liver problems while taking rilpivirine. Liver problems have also occurred in people taking rilpivirine who have no history of liver disease. Liver function tests may be done before and during treatment with rilpivirine.

While taking rilpivirine, it is important to keep all of your appointments with your health care provider.

What is rilpivirine?

Rilpivirine is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults who have never taken HIV medicines before and who have a viral load (number of HIV RNA copies per mL of blood) of 100,000 copies/mL or less at the start of treatment. Rilpivirine is always used in combination with other HIV medicines.

Rilpivirine belongs to a class (group) of HIV drugs called non-nucleoside reverse transcriptase inhibitors (NNRTIs). NNRTIs attach to and block an HIV enzyme called reverse transcriptase. (An enzyme is a protein that starts or increases the speed of a chemical reaction.) By blocking reverse transcriptase, NNRTIs prevent HIV from multiplying and can reduce the amount of HIV in the body.

HIV medicines can’t cure HIV/AIDS, but taking a combination of HIV medicines (called an HIV treatment regimen) every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV transmission. If you are taking HIV medicines, including rilpivirine, don’t cut down on, skip, or stop taking them unless your health care provider tells you to.

What should I tell my health care provider before taking rilpivirine?

Before taking rilpivirine, tell your health care provider:

  • If you are allergic to rilpivirine or any other medicines.
  • If you have had or currently have liver problems, including HBV or HCV infection.
  • If you have ever had a mental health problem.
  • If you have any other medical conditions.  
  • If you are pregnant or plan to become pregnant. Whether rilpivirine can harm an unborn baby is unknown. Rilpivirine should be used during pregnancy only if the potential benefit justifies the potential risk to the unborn baby. Talk to your health care provider about possible risks with taking rilpivirine when pregnant. 
  • If you are breastfeeding or plan to breastfeed. Do not breastfeed if you are infected with HIV or are taking rilpivirine.
  • About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Rilpivirine may affect the way other medicines or products work, and other medicines or products may affect how rilpivirine works. Taking rilpivirine with certain medicines or products may cause serious side effects.

How should I take rilpivirine?

Rilpivirine comes in tablet form, under the brand name Edurant. Each tablet contains 25 mg rilpivirine.

Take rilpivirine according to your health care provider’s instructions.

Always take rilpivirine with a meal. (A protein drink alone does not replace a meal.)

Always take rilpivirine in combination with other HIV medicines.

If you take too much rilpivirine, contact your health care provider or local poison control center (1-800-222-1222) right away, or go to the nearest hospital emergency room. 

For more information on how to take rilpivirine, see the FDA drug label from DailyMed. (DailyMed is a federal website that includes the most recent drug labels submitted to FDA.)

What should I do if I forget a dose?

If you miss a dose of rilpivirine within 12 hours of the time you usually take it, take your dose with a meal as soon as possible. Then take your next dose at the regularly scheduled time. If you miss a dose by more than 12 hours from the time you usually take it, wait and then take the next dose at the regularly scheduled time.

What side effects can rilpivirine cause?

Rilpivirine can cause serious, life-threatening side effects. These include depression, mood changes, and liver problems. (See the WARNING above.)

Other possible side effects of rilpivirine include:

  • Changes in body fat, including loss or gain of fat.
  • Immune reconstitution inflammatory syndrome (IRIS), a condition that sometimes occurs when the immune system begins to recover after treatment with an HIV medicine. As the immune system gets stronger, it may have an increased response to a previously hidden infection. Tell your health care provider if you start having new symptoms after starting your HIV medicine.

Tell your health care provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of rilpivirine. To learn more about possible side effects of rilpivirine, read the drug label or package insert or talk to your health care provider or pharmacist.

The AIDSinfo fact sheet on HIV Medicines and Side Effects also includes information that may apply to rilpivirine.

You can also report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online at https://www.accessdata.fda.gov/scripts/medwatch/.

How should rilpivirine be stored?

  • Store rilpivirine at room temperature, between 68°F and 77°F (20°C to 25°C).
  • Keep rilpivirine in the bottle that it came in and keep the bottle tightly closed. The bottle helps protect rilpivirine from light.
  • Do not use rilpivirine if the original seal over the bottle opening is broken or missing. 
  • Throw away rilpivirine that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine.
  • Keep rilpivirine and all medicines out of reach of children.

Where can I find more information about rilpivirine?

More information about rilpivirine is available:

Manufacturer Information

Janssen Pharmaceuticals, Inc.
800-526-7736

The above Patient Version drug summary is based on the following FDA label(s): Tablet (film coated).

Last Reviewed: May 7, 2015

Last Updated: May 7, 2015


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