RilpivirineBrand Name: Edurant Other Names: RPV, rilpivirine hydrochloride Drug Class: Non-nucleoside Reverse Transcriptase Inhibitors
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Rilpivirine can cause serious, life-threatening side effects. These include severe skin rash,, mood changes, and problems.
Contact your health care provider right away if you get a rash. Stop taking rilpivirine and contact your health care provider or get medical help right away if you have a rash along with any of the following symptoms:
- Blistering skin.
- Sores in your mouth.
- Redness or swelling of your eyes.
- Swelling in your face, lips, mouth, tongue, or throat.
- Trouble breathing or swallowing.
- Pain on the right side of your stomach.
- Dark-colored urine.
Contact your health care provider right away if you have any of the following symptoms that could be signs of depression or mood changes:
- Feeling sad or hopeless.
- Feeling anxious or restless.
- Harming yourself or having thoughts about harming yourself (including suicidal thoughts).
Some people taking rilpivirine have had liver problems. People with a history of
While taking rilpivirine, it is important to keep all of your appointments with your health care provider.
What is rilpivirine?
Rilpivirine is a prescription medicine approved by the U.S.(FDA) for the treatment of HIV infection in adults and children 12 years of age and older who have never taken HIV medicines before and who have a (number of HIV RNA copies per mL of blood) of 100,000 copies/mL or less at the start of treatment. Rilpivirine is always used in combination with other HIV medicines.
Rilpivirine belongs to a class (group) of HIV drugs called non-inhibitors (NNRTIs). NNRTIs attach to and block an HIV called reverse transcriptase. (An enzyme is a that starts or increases the speed of a chemical reaction.) By blocking reverse transcriptase, NNRTIs prevent HIV from multiplying and can reduce the amount of HIV in the body.
HIV medicines can’t cure HIV/AIDS, but taking a combination of HIV medicines (called an HIV regimen) every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV.
What should I tell my health care provider before taking rilpivirine?
Before taking rilpivirine, tell your health care provider:
- If you are allergic to rilpivirine or any other medicines.
- If you have had or currently have liver problems, including HBV or HCV infection.
- If you have ever had a mental health problem.
- If you have any other medical conditions.
- If you are pregnant or plan to become pregnant. Whether rilpivirine can harm an unborn baby is unknown. Rilpivirine should be used during pregnancy only if the potential benefits outweigh the risks. Talk to your health care provider about possible risks with taking rilpivirine when pregnant.
- If you are breastfeeding or plan to breastfeed. Do not breastfeed if you are infected with HIV or are taking rilpivirine.
- If you are using -based birth control (such as pills, injections, or implants).
- About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Rilpivirine may affect the way other medicines or products work, and other medicines or products may affect how rilpivirine works. Taking rilpivirine together with certain medicines or products may cause serious side effects.
How should I take rilpivirine?
Rilpivirine (brand name: Edurant) comes in tablet form. Each tablet contains 25 mg rilpivirine.
Take rilpivirine according to your health care provider’s instructions.
Always take rilpivirine with a meal. (A protein drink alone does not replace a meal.)
Always take rilpivirine in combination with other HIV medicines.
If you take too much rilpivirine, contact your health care provider or local poison control center (1-800-222-1222) right away, or go to the nearest hospital emergency room.
For more information on how to take rilpivirine, see the FDA drug label from DailyMed. (DailyMed is a federal website that includes the most recent drug labels submitted to FDA.)
What should I do if I forget a dose?
If you miss aof rilpivirine within 12 hours of the time you usually take it, take your dose with a meal as soon as possible. Then take your next dose at the regularly scheduled time. If you miss a dose by more than 12 hours from the time you usually take it, wait and then take the next dose at the regularly scheduled time. Do not take two doses at the same time to make up for a missed dose.
What side effects can rilpivirine cause?
Rilpivirine may cause side effects. Most side effects from rilpivirine are manageable, but a few can be serious. Serious side effects of rilpivirine include severe rash, depression, mood changes, and liver problems. (See the WARNING above.)
Other possible side effects of rilpivirine include:
- Changes in body fat (including gain or loss of fat).
- (IRIS), a condition that sometimes occurs when the begins to recover after treatment with an HIV medicine. As the immune system gets stronger, it may have an increased response to a previously hidden infection.
Tell your health care provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of rilpivirine. To learn more about possible side effects of rilpivirine, read the drug label oror talk to your health care provider or pharmacist.
The AIDSinfo fact sheet on HIV Medicines and Side Effects also includes information that may apply to rilpivirine.
You can also report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online at https://www.accessdata.fda.gov/scripts/medwatch/.
How should rilpivirine be stored?
- Store rilpivirine at room temperature, 68°F to 77°F (20°C to 25°C).
- Keep rilpivirine in the bottle that it came in and keep the bottle tightly closed. The bottle helps protect rilpivirine from light.
- Do not use rilpivirine if the original seal over the bottle opening is broken or missing.
- Throw away rilpivirine that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine.
- Keep rilpivirine and all medicines out of reach of children.
Where can I find more information about rilpivirine?
More information about rilpivirine is available:
Janssen Pharmaceuticals, Inc.
The above Patient Version drug summary is based on the following FDA label(s): Tablet (film coated).
Last Reviewed: May 18, 2016