ItraconazoleOther Names: Sporanox Drug Class: Opportunistic Infections and Coinfections
What is itraconazole?
Itraconazole is anprescription medicine approved by the U.S. (FDA) for the treatment of certain fungal infections, including (also known as Histoplasma capsulatum infection), esophageal , oropharyngeal candidiasis, and others.
Esophageal candidiasis (infection of the esophagus) and oropharyngeal candidiasis (infection of part of the throat) are types of What is an Opportunistic Infection? fact sheet.candidiasis (also called mucosal candidiasis). Mucocutaneous candidiasis and histoplasmosis are both opportunistic infections (OIs) of HIV. An OI is an infection that occurs more frequently or is more severe in people with weakened immune systems—such as people with HIV—than in people with healthy immune systems. To learn more about OIs, read the
How is itraconazole used in people with HIV?
The Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents include recommendations on the HIV-related uses of itraconazole.
Using a medicine as indicated on the medicine label is called on-label use; using the medicine in a different way is called. Off-label use, for example, can include using a drug for a different disease or medical condition. Good medical practice and the best interests of a patient sometimes require that a medicine be used off-label.
The guidelines include recommendations on the following uses of itraconazole:
- Treatment of histoplasmosis, esophageal candidiasis, and oropharyngeal candidiasis
- Treatment of:
- , specifically caused by certain types of microsporidia
- Uncomplicated vulvovaginal candidiasis (a type of mucocutaneous candidiasis)
- Penicilliosis marneffei
- Prevention of:
- Histoplasmosis from occurring the first time (called ) and from recurring (called secondary or )
- Primary and secondary prophylaxis of Penicilliosis marneffei
- Secondary prophylaxis of coccidioidomycosis
- Secondary prophylaxis of oropharyngeal candidiasis
The above list may not include all of the HIV-related uses of itraconazole recommended in the guidelines. Some recommended uses, such as uses in certain rare circumstances, may have been omitted.
What should I tell my health care provider before taking itraconazole?
Before taking itraconazole, tell your health care provider:
- If you are allergic to itraconazole or any other medicines.
- About any medical conditions you have or have had, for example, or problems.
- About anything that could affect your ability to take medicines, such as difficulty swallowing or remembering to take pills.
- If you are pregnant or plan to become pregnant. Itraconazole should be used for the treatment of fungal infections in pregnancy only if the benefit outweighs the potential risk. Itraconazole should not be used for fungal nail infections during pregnancy or by someone planning to become pregnant within 2 months of treatment. Talk to your health care provider about possible risks with taking itraconazole when pregnant.
- If you are breastfeeding or plan to breastfeed. Do not breastfeed if you have HIV.
- About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Itraconazole may affect the way other medicines or products work, and other medicines or products may affect how itraconazole works. Ask your health care provider if there are interactions between itraconazole and the other medicines you take.
Ask your health care provider about possible side effects from itraconazole. Your health care provider will tell you what to do if you have side effects.
How should I take itraconazole?
Take itraconazole according to your health care provider’s instructions. Your health care provider will tell you how much itraconazole to take and when to take it. Before you start itraconazole and each time you get a refill, read any printed information that comes with your medicine.
How should itraconazole be stored?
- Store itraconazole capsules at room temperature, 59°F to 77°F (15°C to 25°C). Protect the capsules from light and moisture.
- Store itraconazole oral solution at or below 77°F (25°C). Do not freeze the oral solution.
- Do not use itraconazole if the original seal over the container opening is broken or missing.
- Throw away itraconazole that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine.
- Keep itraconazole and all medicines out of reach of children.
Where can I find more information about itraconazole?
More information about itraconazole is available:
- Recommendations on the HIV-related uses of itraconazole, from the Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents, prepared by the , the , and the HIV Medicine Association of the Diseases Society of America
- Itraconazole-related research studies, from the AIDSinfo database of study summaries
Last Reviewed: January 10, 2018