Pyrazinamide is an antibacterial prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of active tuberculosis (TB). TB is an opportunistic infection. An opportunistic infection is an infection that occurs more frequently or is more severe in people with weakened immune systems—such as those infected with HIV—than in people with healthy immune systems.
The Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents, prepared by the Centers for Disease Control and Prevention (CDC), the National Institutes of Health (NIH), and the HIV Medicine Association of the Infectious Diseases Society of America (IDSA-HIVMA), includes recommendations on the HIV-related use of pyrazinamide to treat active TB disease.The above may not include all of the HIV-related uses of pyrazinamide recommended in the Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents. Some recommended uses, such as uses in certain rare circumstances, may have been omitted.
Before taking pyrazinamide, tell your health care provider:
Ask your health care provider about possible side effects from pyrazinamide. Your health care provider will tell you what to do if you have side effects.
Take pyrazinamide according to your health care provider’s instructions. Your health care provider will tell you how much pyrazinamide to take and when to take it. Before you start pyrazinamide and each time you get a refill, read any printed information that comes with your medicine.
More information about pyrazinamide is available:
Last Reviewed: February 12, 2015