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AIDSinfo Drug Database

AIDSinfo Drug Database

Drugs by class



Pyrazinamide  Audio icon

Other Names: PZA
Drug Class: Opportunistic Infections and Coinfections

Chemical Image:
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Molecular Weight: 123.115

What is pyrazinamide?

Pyrazinamide is an antibacterial prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of active tuberculosis (TB). TB is an opportunistic infection. An opportunistic infection is an infection that occurs more frequently or is more severe in people with weakened immune systems—such as those infected with HIV—than in people with healthy immune systems.

The Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents, prepared by the Centers for Disease Control and Prevention (CDC), the National Institutes of Health (NIH), and the HIV Medicine Association of the Infectious Diseases Society of America (IDSA-HIVMA), includes recommendations on the HIV-related use of pyrazinamide to treat active TB disease.

The above may not include all of the HIV-related uses of pyrazinamide recommended in the Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents. Some recommended uses, such as uses in certain rare circumstances, may have been omitted.

What should I tell my health care provider before taking pyrazinamide?

Before taking pyrazinamide, tell your health care provider:

  • If you are allergic to pyrazinamide or any other medicines.
  • About any medical conditions you have or have had, for example, diabetes or liver problems.
  • About anything that could affect your ability to take medicines, such as difficulty swallowing or remembering to take pills.
  • If you are pregnant or plan to become pregnant. Whether pyrazinamide can harm an unborn baby is unknown. Pyrazinamide should be given to a pregnant woman only if clearly needed. Talk to your health care provider about possible risks with taking pyrazinamide when pregnant.
  • If you are breastfeeding or plan to breastfeed. Do not breastfeed if you are infected with HIV.
  • About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Pyrazinamide may affect the way other medicines or products work, and other medicines or products may affect how pyrazinamide works. Ask your health care provider if there are interactions between pyrazinamide and the other medicines you take.

Ask your health care provider about possible side effects from pyrazinamide. Your health care provider will tell you what to do if you have side effects.

How should I take pyrazinamide?

Take pyrazinamide according to your health care provider’s instructions. Your health care provider will tell you how much pyrazinamide to take and when to take it. Before you start pyrazinamide and each time you get a refill, read any printed information that comes with your medicine.

How should pyrazinamide be stored?

  • Store pyrazinamide tablets in a well-closed container at room temperature, 59°F to 86°F (15°C to 30°C).
  • Throw away pyrazinamide that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine. 
  • Keep pyrazinamide and all medicines out of reach of children.

Where can I find more information about pyrazinamide?

More information about pyrazinamide is available:

The above Patient Version drug summary is based on the following FDA label(s): Tablet.

Last Reviewed: February 12, 2015

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