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AIDSinfo Drug Database

AIDSinfo Drug Database

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Moxifloxacin Hydrochloride  Audio icon

Other Names: Avelox, moxifloxacin HCl
Drug Class: Opportunistic Infections and Coinfections
Chemical Image:
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moxifloxacin hydrochloride
moxifloxacin hydrochloride
Molecular Weight: 437.897

What is moxifloxacin hydrochloride?

Moxifloxacin hydrochloride is an antibacterial prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of certain infections, such as acute worsening of chronic bronchitis; pneumonia; and skin, abdominal, and acute sinus infections.

Certain bacterial respiratory diseases (such as pneumonia) are opportunistic infections. An opportunistic infection is an infection that occurs more frequently or is more severe in people with weakened immune systems—such as those infected with HIV—than in people with healthy immune systems.

Moxifloxacin hydrochloride can also be used “off-label” to treat other opportunistic infections of HIV infection. “Off-label” use refers to use of an FDA-approved medicine in a manner different from that described on the medicine label. Good medical practice and the best interests of a patient sometimes require that a medicine be used “off-label.”

What HIV-related opportunistic infections is moxifloxacin hydrochloride used for?

The Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents, prepared by the Centers for Disease Control and Prevention (CDC), the National Institutes of Health (NIH), and the HIV Medicine Association of the Infectious Diseases Society of America (IDSA-HIVMA), includes recommendations on the HIV-related uses of moxifloxacin hydrochloride to:

  • Prevent:
    • Disseminated Mycobacterium avium complex (MAC) disease from recurring (called secondary prophylaxis or maintenance therapy). (This is an "off-label" use.) 
  • Treat:
    • Disseminated MAC disease. (This is an "off-label" use.) 
    • Active tuberculosis (TB) disease. (This is an "off-label" use.) 
    • Certain bacterial enteric infections, such as salmonellosis (also known as Salmonella infection), shigellosis, and campylobacteriosis. (This is an "off-label" use.) 
    • Certain bacterial respiratory diseases, including pneumonia.
The above list may not include all of the HIV-related uses of moxifloxacin hydrochloride recommended in the Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents. Some recommended uses, such as uses in certain rare circumstances, may have been omitted.

What should I tell my health care provider before taking moxifloxacin hydrochloride?

Before taking moxifloxacin hydrochloride, tell your health care provider:

  • If you are allergic to moxifloxacin hydrochloride or any other medicines.
  • About any medical conditions you have or have had, for example, diabetes or liver problems. 
  • About anything that could affect your ability to take medicines, such as difficulty swallowing pills, difficulty remembering to take pills, or any health conditions that may prevent your use of intravenous medicines. 
  • If you are pregnant or plan to become pregnant. Whether moxifloxacin hydrochloride can harm an unborn baby is unknown. Talk to your health care provider about possible risks with taking moxifloxacin hydrochloride when pregnant. 
  • If you are breastfeeding or plan to breastfeed. Do not breastfeed if you are infected with HIV.
  • About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Moxifloxacin hydrochloride may affect the way other medicines or products work, and other medicines or products may affect how moxifloxacin hydrochloride works. Ask your health care provider if there are interactions between moxifloxacin hydrochloride and the other medicines you take.

Ask your health care provider about possible side effects from moxifloxacin hydrochloride. Your health care provider will tell you what to do if you have side effects.

How should I take moxifloxacin hydrochloride?

Take moxifloxacin hydrochloride according to your health care provider’s instructions. Your health care provider will tell you how much moxifloxacin hydrochloride to take and when to take it. Before you start moxifloxacin hydrochloride and each time you get a refill, read any printed information that comes with your medicine.

How should moxifloxacin hydrochloride be stored?

  • Store moxifloxacin hydrochloride tablets at 59°F to 86°F (15°C to 30°C) and away from moisture (humidity).
  • Store moxifloxacin hydrochloride injection solution at 59°F to 86°F (15°C to 30°C). Do not refrigerate ready-to-use bags of moxifloxacin hydrochloride solution.
  • Do not use moxifloxacin hydrochloride if the original seal on the medicine container is broken or missing. 
  • Throw away moxifloxacin hydrochloride that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine. 
  • Keep moxifloxacin hydrochloride and all medicines out of reach of children.

Where can I find more information about moxifloxacin hydrochloride?

More information about moxifloxacin hydrochloride is available:

The above Patient Version drug summary is based on the following FDA label(s): Injection (solution), tablet (film coated).

Last Reviewed: April 15, 2015

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