Drugs

Voriconazole

Voriconazole

Other Names: VFEND Drug Class: Opportunistic Infections and Coinfections
What is voriconazole?

What is voriconazole?

Voriconazole is an antifungal prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of certain fungal infections, such as esophageal candidiasis. (Esophageal candidiasis is an infection of the esophagus.)

Esophageal candidiasis is an opportunistic infection (OI) of HIV. An OI is an infection that occurs more frequently or is more severe in people with weakened immune systems—such as people with HIV—than in people with healthy immune systems. To learn more about OIs, read the AIDSinfo What is an Opportunistic Infection? fact sheet.

How is voriconazole used in people with HIV?

How is voriconazole used in people with HIV?

The Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents include recommendations on the HIV-related uses of voriconazole.

Using a medicine as indicated on the medicine label is called on-label use; using the medicine in a different way is called off-label use. Off-label use, for example, can include using a drug for a different disease or medical condition. Good medical practice and the best interests of a patient sometimes require that a medicine be used off-label.

The guidelines include recommendations on the on-label use of voriconazole to treat esophageal candidiasis. The off-label uses of voriconazole are to treat:

In addition, preventing coccidioidomycosis from recurring (called secondary prophyalxis or maintenance therapy) is an off-label use of voriconazole.

The above list may not include all of the HIV-related uses of voriconazole recommended in the guidelines. Some recommended uses, such as uses in certain rare circumstances, may have been omitted.

What should I tell my health care provider before taking voriconazole?

What should I tell my health care provider before taking voriconazole?

Before taking voriconazole, tell your health care provider:

  • If you are allergic to voriconazole or any other medicines.
  • About any medical conditions you have or have had, for example, diabetes or liver problems.
  • About anything that could affect your ability to take medicines, such as difficulty swallowing tablets, difficulty remembering to take tablets, or any health conditions that may prevent your use of intravenous medicines.
  • If you have trouble digesting dairy products, milk sugar (lactose), or table sugar.
  • If you are pregnant or plan to become pregnant. Voriconazole can harm your unborn baby. Talk to your health care provider about possible risks with taking voriconazole when pregnant.
  • If you are breastfeeding or plan to breastfeed. Do not breastfeed if you have HIV.
  • About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Voriconazole may affect the way other medicines or products work, and other medicines or products may affect how voriconazole works. Ask your health care provider if there are interactions between voriconazole and the other medicines you take.

Ask your health care provider about possible side effects from voriconazole. Your health care provider will tell you what to do if you have side effects.

How should I take voriconazole?

How should I take voriconazole?

Take voriconazole according to your health care provider’s instructions. Your health care provider will tell you how much voriconazole to take and when to take it. Before you start voriconazole and each time you get a refill, read any printed information that comes with your medicine.

How should voriconazole be stored?

How should voriconazole be stored?

  • Store vials of voriconazole powder for injection solution at 59°F to 86°F (15°C to 30°C). After reconstitution with water, the solution should be used immediately. Only clear solution without particles should be used.
  • Store voriconazole tablets at 59°F to 86°F (15°C to 30°C).
  • Store voriconazole powder for oral suspension in a refrigerator at 36°F to 46°F (2°C to 8°C) before reconstitution. After reconstitution, the oral suspension should be stored at 59°F to 86°F (15°C to 30°C). Do not refrigerate or freeze it. Any remaining oral suspension should be thrown away 14 days after reconstitution.
  • Do not use voriconazole if the original seal over the container opening is broken or missing.
  • Throw away voriconazole that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine.
  • Keep voriconazole and all medicines out of reach of children.

Where can I find more information about voriconazole?

Where can I find more information about voriconazole?

More information about voriconazole is available:

The above Patient Version drug summary is based on the following FDA label(s): Injection, powder, tablet (film coated).

Last Reviewed: January 11, 2018