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AIDSinfo Drug Database

AIDSinfo Drug Database

Drugs by class



Butoconazole Nitrate  Audio icon

Other Names: Gynazole, Gynazole-1
Drug Class: Opportunistic Infections and Coinfections

Chemical Image:
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butoconazole nitrate
butoconazole nitrate
Molecular Weight: 474.7942

Information Type

What is butoconazole nitrate?

Butoconazole nitrate is an antifungal prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of vulvovaginal candidiasis, which is an infection of the female vulva and vagina. Vulvovaginal candidiasis is a type of mucocutaneous candidiasis.

Vulvovaginal candidiasis is an opportunistic infection. An opportunistic infection is an infection that occurs more frequently or is more severe in people with weakened immune systems—such as those infected with HIV—than in people with healthy immune systems.

The Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents, prepared by the Centers for Disease Control and Prevention (CDC), the National Institutes of Health (NIH), and the HIV Medicine Association of the Infectious Diseases Society of America (IDSA-HIVMA), includes recommendations on the HIV-related use of butoconazole nitrate to treat uncomplicated vulvovaginal candidiasis.

The above may not include all of the HIV-related uses of butoconazole nitrate recommended in the Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents. Some recommended uses, such as uses in certain rare circumstances, may have been omitted.

What should I tell my health care provider before taking butoconazole nitrate?

Before taking butoconazole nitrate, tell your health care provider:

  • If you are allergic to butoconazole nitrate or any other medicines.
  • About any medical conditions you have or have had, for example, diabetes or liver problems.
  • About anything that could affect your ability to take medicines, such as difficulty with remembering a scheduled dose.
  • If you are pregnant or plan to become pregnant. Whether butoconazole nitrate can harm an unborn baby is unknown. Butoconazole nitrate should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Talk to your health care provider about possible risks with taking butoconazole nitrate when pregnant.
  • If you are breastfeeding or plan to breastfeed. Do not breastfeed if you are infected with HIV.
  • About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Butoconazole nitrate may affect the way other medicines or products work, and other medicines or products may affect how butoconazole nitrate works. Ask your health care provider if there are interactions between butoconazole nitrate and the other medicines you take.

Ask your health care provider about possible side effects from butoconazole nitrate. Your health care provider will tell you what to do if you have side effects.

How should I take butoconazole nitrate?

Take butoconazole nitrate according to your health care provider’s instructions. Your health care provider will tell you how much butoconazole nitrate to take and when to take it. Before you start butoconazole nitrate and each time you get a refill, read any printed information that comes with your medicine.

How should butoconazole nitrate be stored?

  • Store butoconazole nitrate cream at 68°F to 77°F (20°C to 25°C). Avoid heat above 86°F (30°C).
  • Do not use butoconazole nitrate if the original seal over the applicator opening is broken or missing.
  • Throw away butoconazole nitrate that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine.
  • Keep butoconazole nitrate and all medicines out of reach of children.

Where can I find more information about butoconazole nitrate?

More information about butoconazole nitrate is available:

The above Patient Version drug summary is based on the following FDA label(s): Cream.

Last Reviewed: April 26, 2015

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