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AIDSinfo Drug Database

AIDSinfo Drug Database

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FDA-approved

Investigational

Podofilox  Audio icon

Other Names: Condylox, podophyllotoxin
Drug Class: Opportunistic Infections and Coinfections
Chemical Image:
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Podofilox
Podofilox
Molecular Weight: 414.4078

What is podofilox?

Podofilox is an antimitotic prescription medicine. (Antimitotic means blocking cell growth by stopping cell division.) Podofilox comes in two forms: a gel and a solution. The gel form of podofilox is approved by the U.S. Food and Drug Administration (FDA) for the topical treatment of external genital warts and perianal warts. The solution form of podofilox is FDA-approved for the topical treatment of external genital warts.

External genital warts and perianal warts are caused by the human papillomavirus (HPV). HPV is an opportunistic infection. An opportunistic infection is an infection that occurs more frequently or is more severe in people with weakened immune systems—such as those infected with HIV—than in people with healthy immune systems.

What HIV-related opportunistic infections is podofilox used for?

The Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents, prepared by the Centers for Disease Control and Prevention (CDC), the National Institutes of Health (NIH), and the HIV Medicine Association of the Infectious Diseases Society of America (IDSA-HIVMA), include recommendations on the HIV-related use of podofilox to treat external genital warts caused by HPV.

The above paragraph may not include all of the HIV-related uses of podofilox recommended in the Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents. Some recommended uses, such as uses in certain rare circumstances, may have been omitted.

What should I tell my health care provider before taking podofilox?

Before taking podofilox, tell your health care provider:

  • If you are allergic to podofilox or any other medicines.
  • About any medical conditions you have or have had, for example, diabetes or liver problems. 
  • About anything that could affect your ability to use podofilox, such as difficulty with applying a solution or gel to the affected area or trouble with remembering a scheduled dose.
  • If you are pregnant or plan to become pregnant. Whether podofilox can harm an unborn baby is unknown. Podofilox should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus. Talk to your health care provider about possible risks with taking podofilox when pregnant.
  • If you are breastfeeding or plan to breastfeed. Do not breastfeed if you are infected with HIV.
  • About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Podofilox may affect the way other medicines or products work, and other medicines or products may affect how podofilox works. Ask your health care provider if there are interactions between podofilox and the other medicines you take.

Ask your health care provider about possible side effects from podofilox. Your health care provider will tell you what to do if you have side effects.

How should I take podofilox?

Take podofilox according to your health care provider’s instructions. Your health care provider will tell you how much podofilox to use and when to use it. Before you start podofilox and each time you get a refill, read any printed information that comes with your medicine.

How should podofilox be stored?

  • Store podofilox gel and solution at room temperature, 68°F to 77°F (20°C to 25°C). Avoid excessive heat. Do not freeze the gel or solution.
  • Do not use podofilox if the original seal over the container opening is broken or missing.
  • Throw away podofilox that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine.
  • Keep podofilox and all medicines out of reach of children.

Where can I find more information about podofilox?

More information about podofilox is available:

 

The above Patient Version drug summary is based on the following FDA label(s): Gel; Solution.

Last Reviewed: June 11, 2015

Last Updated: June 11, 2015


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