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Sinecatechins

Sinecatechins

Other Names: Veregen Drug Class: Opportunistic Infections and Coinfections
What is sinecatechins?

What is sinecatechins?

Sinecatechins topical ointment is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of external genital and perianal warts (warts on the outside of the genitals and anus) caused by the human papillomavirus (HPV). The drug is approved for use in immunocompetent people 18 years of age and older. Immunocompetent means having a healthy immune system that can fight off infections normally.

In people with HIV, HPV Infection is an opportunistic infection. An opportunistic infection is an infection that occurs more frequently or is more severe in people with weakened immune systems—such as those infected with HIV—than in people with healthy immune systems. To learn more about opportunistic infections, read the AIDSinfo What is an Opportunistic Infection? fact sheet.

Although sinecatechins’ safety and effectiveness in people with weakened immune systems is unknown, the drug can also be used off-label in people with HIV. Off-label use refers to use of an FDA-approved medicine in a manner different from that described on the medicine label. Good medical practice and the best interests of a patient sometimes require that a medicine be used off-label.

How is sinecatechins used in people with HIV?

How is sinecatechins used in people with HIV?

The Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents, prepared by the Centers for Disease Control and Prevention (CDC), the National Institutes of Health (NIH), and the HIV Medicine Association of the Infectious Diseases Society of America (IDSA-HIVMA), include recommendations on the use of sinecatechins to treat external genital and perianal warts caused by HPV infection in people with HIV. (This use of sinecatechins is considered off-label because people with HIV have weakened immune systems and sinecatechins is approved for use in immunocompetent people.)

The above paragraph may not include all of the HIV-related uses of sinecatechins recommended in the Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents. Some recommended uses, such as uses in certain rare circumstances, may have been omitted.

What should I tell my health care provider before taking sinecatechins?

What should I tell my health care provider before taking sinecatechins?

Before taking sinecatechins, tell your health care provider:

  • If you are allergic to sinecatechins or any other medicines.
  • About any medical conditions you have or have had, for example, diabetes or liver problems. 
  • Whether you are using any other type of skin product or have open wounds on the area to be treated. Sinecatechins should not be used until your skin has healed from other treatments applied to the same area.
  • Whether you have a weakened immune system.
  • About anything that could affect your ability to use sinecatechins, such as difficulty with applying an ointment to the affected area or trouble with remembering a scheduled dose
  • If you are pregnant or plan to become pregnant. Whether sinecatechins can harm an unborn baby is unknown. Sinecatechins should be used during pregnancy only if the potential benefits outweigh the risks. Talk to your health care provider about possible risks with taking sinecatechins when pregnant.
  • If you are breastfeeding or plan to breastfeed. Do not breastfeed if you are infected with HIV.
  • About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Sinecatechins may affect the way other medicines or products work, and other medicines or products may affect how sinecatechins works. Ask your health care provider if there are interactions between sinecatechins and the other medicines you take.

Ask your health care provider about possible side effects from sinecatechins. Your health care provider will tell you what to do if you have side effects.

How should I take sinecatechins?

How should I take sinecatechins?

Take sinecatechins according to your health care provider’s instructions. Your health care provider will tell you how much sinecatechins to take and when to take it. Before you start sinecatechins and each time you get a refill, read any printed information that comes with your medicine.

How should sinecatechins be stored?

How should sinecatechins be stored?

  • Store sinecatechins ointment in the refrigerator or up to 77°F (25°C). Do not freeze it.
  • Make sure the cap on the tube is tightly closed.
  • Do not use sinecatechins if the original seal over the container opening is broken or missing. 
  • Throw away sinecatechins that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine.
  • Keep sinecatechins and all medicines out of reach of children.

Where can I find more information about sinecatechins?

Where can I find more information about sinecatechins?

More information about sinecatechins is available:

The above Patient Version drug summary is based on the following FDA label(s): Ointment.

Last Reviewed: May 9, 2017

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