skip navigation

Skip Nav

AIDSinfo Drug Database

AIDSinfo Drug Database

Drugs by class



Tenofovir Disoproxil Fumarate  Audio icon

Other Names: TDF, Viread, tenofovir DF
Drug Class: Opportunistic Infections and Coinfections

Chemical Image:
Click image to enlarge
tenofovir disoproxil fumarate
tenofovir disoproxil fumarate
Molecular Weight: 635.5166

What is tenofovir disoproxil fumarate?

Tenofovir disoproxil fumarate (tenofovir DF) is a type of anti-HIV medicine called a nucleoside reverse transcriptase inhibitor (NRTI). The prescription medicine is approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults and children 2 years of age and older. Tenofovir DF is always used in combination with other anti-HIV medicines.

Tenofovir DF is also a hepatitis B virus (HBV) reverse transcriptase inhibitor, approved by the FDA for the treatment of chronic HBV infection in adults. HBV is an opportunistic infection. An opportunistic infection is an infection that occurs more frequently or is more severe in people with weakened immune systems—such as those infected with HIV—than in people with healthy immune systems.

The Guidelines for Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents, prepared by the U.S. Department of Health and Human Services (HHS) and the Centers for Disease Control and Prevention (CDC), includes recommendations on the use of tenofovir DF to treat HBV infection in people who are also receiving combination antiretroviral therapy (ART) for HIV infection.

What should I tell my health care provider before taking tenofovir disoproxil fumarate?

Before taking tenofovir DF, tell your health care provider:

  • If you are allergic to tenofovir DF or any other medicines.
  • About any medical conditions you have or have had, for example, diabetes or liver problems. 
  • About anything that could affect your ability to take medicines, such as difficulty swallowing or remembering to take pills.
  • If you are pregnant or plan to become pregnant. Whether tenofovir DF can harm an unborn baby is unknown.
  • If you are breastfeeding or plan to breastfeed. Do not breastfeed if you are infected with HIV.
  • About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Ask your health care provider if there are interactions between tenofovir DF and the other medicines you take.

Ask your health care provider about possible side effects from tenofovir DF. Your health care provider will tell you what to do if you have side effects.

How should I take tenofovir disoproxil fumarate?

Take tenofovir DF according to your health care provider’s instructions. Your health care provider will tell you how much tenofovir DF to take and when to take it. Before you start tenofovir DF and each time you get a refill, read any printed information that comes with your medicine.

How should tenofovir disoproxil fumarate be stored?

  • Store tenofovir DF tablets and oral powder between 59°F and 86°F (15°C to 30°C).
  • Keep tenofovir DF in the original container.
  • Do not use tenofovir DF if the seal over the bottle opening is broken or missing.
  • Keep the tenofovir DF medication bottle tightly closed.
  • Safely throw away tenofovir DF that is no longer needed or expired (out of date).
  • Keep tenofovir DF and all medicines out of reach of children.

Where can I find more information about tenofovir disoproxil fumarate?

More information about tenofovir DF is available:

The above Patient Version drug summary is based on the following FDA label(s): Powder; tablet (coated).

Back to Top