FluconazoleOther Names: Diflucan Drug Class: Opportunistic Infections and Coinfections
What is fluconazole?
Fluconazole is anprescription medicine approved by the U.S. (FDA) for the treatment of esophageal , oropharyngeal candidiasis, vaginal candidiasis, and . It is also approved to decrease the chance of candidiasis in people undergoing transplantation who receive and/or radiation therapy.
Esophageal candidiasis (What is an Opportunistic Infection? fact sheet.of the esophagus), oropharyngeal candidiasis (infection of part of the throat), and vaginal candidiasis (infection of the vagina) are all examples of candidiasis (also called mucosal candidiasis). Cryptococcal is an infection and inflammation of the tissues covering the brain and spinal cord. Mucocutaneous candidiasis and cryptococcal meningitis are opportunistic infections (OIs) of HIV. An OI is an infection that occurs more frequently or is more severe in people with weakened immune systems—such as people with HIV—than in people with healthy immune systems. To learn more about OIs, read the
How is fluconazole used in people with HIV?
The Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents include recommendations on the uses of fluconazole in people with HIV.
Using a medicine as indicated on the medicine label is called; using the medicine in a different way is called . Off-label use, for example, can include using a drug for a different disease or medical condition. Good medical practice and the best interests of a patient sometimes require that a medicine be used off-label.
The guidelines include recommendations on the following uses of fluconazole:
- Mucocutaneous candidiasis, including esophageal candidiasis, oropharyngeal candidiasis, and vulvovaginal candidiasis
- Prevent cryptococcal meningitis from recurring (called secondary or )
- (also known as Histoplasma capsulatum infection)
- Coccidioidomycosis from occurring the first time (called ) and from recurring
- Histoplasmosis from recurring
- Penicilliosis (also known as Penicillium marneffei infection) from occurring the first time
- Mucocutaneous candidiasis, including esophageal candidiasis, oropharyngeal candidiasis, and vulvovaginal candidiasis, from recurring
The above list may not include all of the HIV-related uses of fluconazole recommended in the guidelines. Some recommended uses, such as uses in certain rare circumstances, may have been omitted.
What should I tell my health care provider before taking fluconazole?
Before taking fluconazole, tell your health care provider:
- If you are allergic to fluconazole or any other medicines.
- About any medical conditions you have or have had, for example, or problems.
- About anything that could affect your ability to take medicines, such as difficulty swallowing tablets, difficulty remembering to take tablets, or any health conditions that may prevent your use of medicines.
- If you are pregnant or plan to become pregnant. Fluconazole may cause birth defects. A few cases of birth defects in children born to women who received high fluconazole during pregnancy have been reported. Talk to your health care provider about possible risks with taking fluconazole when pregnant.
- If you are breastfeeding or plan to breastfeed. Do not breastfeed if you have HIV.
- About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Fluconazole may affect the way other medicines or products work, and other medicines or products may affect how fluconazole works. Ask your health care provider if there are interactions between fluconazole and the other medicines you take.
Ask your health care provider about possible side effects from fluconazole. Your health care provider will tell you what to do if you have side effects.
How should I take fluconazole?
Take fluconazole according to your health care provider’s instructions. Your health care provider will tell you how much fluconazole to take and when to take it. Before you start fluconazole and each time you get a refill, read any printed information that comes with your medicine.
How should fluconazole be stored?
- Store fluconazole tablets below 86°F (30°C).
- Store fluconazole powder for oral suspension below 86°F (30°C).
- Store reconstituted fluconazole suspension between 41°F and 86°F (5°C to 30°C) and throw away the unused portion after 2 weeks. Protect from freezing.
- Store plastic containers of fluconazole for intravenous between 41°F and 77°F (5°C to 25°C). Brief exposure up to 104°F (40°C) does not adversely affect the medicine. Protect from freezing and avoid excessive heat.
- Keep fluconazole in the container that it came in and keep the container tightly closed.
- Do not use fluconazole if the original seal over the container opening is broken or missing.
- Throw away fluconazole that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine.
- Keep fluconazole and all medicines out of reach of children.
Where can I find more information about fluconazole?
More information about fluconazole is available:
- Recommendations on the HIV-related uses of fluconazole, from the Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents, prepared by the , the , and the HIV Medicine Association of the Diseases Society of America
- Fluconazole-related research studies, from the AIDSinfo database of study summaries
Last Reviewed: March 27, 2019