Twinrix is a vaccine approved by the U.S. Food and Drug Administration (FDA) to prevent infection caused by hepatitis A virus (HAV) and hepatitis B virus (HBV) infection in adults 18 years of age and older. HAV infection and HBV infection are HIV-related opportunistic infections. An opportunistic infection is an infection that occurs more frequently or is more severe in people with weakened immune systems—such as those infected with HIV—than in people with healthy immune systems.
The Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents, prepared by the Centers for Disease Control and Prevention (CDC), the National Institutes of Health (NIH), and the HIV Medicine Association of the Infectious Diseases Society of America (IDSA-HIVMA), includes recommendations on the use of Twinrix in HIV-infected individuals.
Before receiving Twinrix, tell your health care provider:
Ask your health care provider about possible side effects from Twinrix. Your health care provider will tell you what to do if you have side effects.
A health care provider gives the Twinrix vaccine. The vaccine is injected into a muscle in the arm. Vaccination with Twinrix is usually given as a series of either three or four vaccine shots over a 6- to 12-month period. Read any printed information that your health care provider gives you about the hepatitis A and hepatitis B (recombinant) vaccine.
More information about the hepatitis A and hepatitis B (recombinant) vaccine is available:
Last Reviewed: April 24, 2015