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AIDSinfo Drug Database

AIDSinfo Drug Database

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Hepatitis A and Hepatitis B (Recombinant) Vaccine  Audio icon

Other Names: Twinrix, combined HAV and HBV vaccine, hepatitis A and B virus vaccine
Drug Class: Opportunistic Infections and Coinfections

What is Twinrix?

Twinrix is a vaccine approved by the U.S. Food and Drug Administration (FDA) to prevent infection caused by hepatitis A virus (HAV) and hepatitis B virus (HBV) infection in adults 18 years of age and older. HAV infection and HBV infection are HIV-related opportunistic infections. An opportunistic infection is an infection that occurs more frequently or is more severe in people with weakened immune systems—such as those infected with HIV—than in people with healthy immune systems.

The Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents, prepared by the Centers for Disease Control and Prevention (CDC), the National Institutes of Health (NIH), and the HIV Medicine Association of the Infectious Diseases Society of America (IDSA-HIVMA), includes recommendations on the use of Twinrix in HIV-infected individuals.

What should I tell my health care provider before receiving Twinrix?

Before receiving Twinrix, tell your health care provider: 

  • If you are allergic to yeast, any other ingredients in Twinrix, or any medicines. Tell your health care provider if you have ever had any reactions to a previous dose of the vaccine or to any other hepatitis A and hepatitis B vaccines.
  • About any medical conditions you have or have had, for example, diabetes or liver problems.
  • If you are pregnant or plan to become pregnant. Whether Twinrix can harm an unborn baby is unknown, and Twinrix should be given to a pregnant woman only if clearly needed. Talk to your health care provider about possible risks with taking Twinrix when pregnant.
  • If you are breastfeeding or plan to breastfeed. Do not breastfeed if you are infected with HIV.
  • About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Twinrix may affect the way other medicines or products work, and other medicines or products may affect how Twinrix works. Ask your health care provider if there are interactions between Twinrix and the medicines you take.

Ask your health care provider about possible side effects from Twinrix. Your health care provider will tell you what to do if you have side effects.

How is Twinrix given?

A health care provider gives the Twinrix vaccine. The vaccine is injected into a muscle in the arm. Vaccination with Twinrix is usually given as a series of either three or four vaccine shots over a 6- to 12-month period. Read any printed information that your health care provider gives you about the hepatitis A and hepatitis B (recombinant) vaccine.

Where can I find more information about Twinrix?

More information about the hepatitis A and hepatitis B (recombinant) vaccine is available:

The above Patient Version drug summary is based on the following FDA label(s): Injection (suspension).

Last Reviewed: April 24, 2015

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