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AIDSinfo Drug Database

AIDSinfo Drug Database

Drugs by class



Elvitegravir / Cobicistat / Emtricitabine / Tenofovir Disoproxil Fumarate  Audio icon

Brand Name: Stribild
Other Names: EVG / COBI / FTC / TDF, QUAD
Drug Class: Combination Drugs
Approved Use: Treatment of HIV Infection
Drug Image:
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Chemical Images:
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Molecular Weight: 447.8877
Molecular Weight: 776.0347
Molecular Weight: 247.249
tenofovir disoproxil fumarate
tenofovir disoproxil fumarate
Molecular Weight: 635.5166


Stribild can cause serious, life-threatening side effects. These include lactic acidosis (buildup of lactic acid in the blood) and liver problems.

Contact your health care provider right away if you have any of the following symptoms that could be signs of lactic acidosis:

  • Weakness or tiredness.
  • Unusual (not normal) muscle pain.
  • Trouble breathing.
  • Stomach pain with nausea and vomiting.
  • Feeling cold, especially in your arms and legs.
  • Dizziness or lightheadedness.
  • Fast or irregular heartbeat.

Contact your health care provider right away if you have any of the following symptoms that could be signs of signal liver problems:

  • Yellowing of your skin or the whites of your eyes (jaundice).
  • Dark-colored urine.
  • Light-colored bowel movements.
  • Loss of appetite for several days or longer.
  • Feeling sick to your stomach (nausea).
  • Pain in the stomach area (abdominal pain).

Stribild is not approved for the treatment of hepatitis B virus (HBV) infection. If you have both HIV and HBV infection and take Stribild, your HBV infection may get worse (flare up) if you stop taking Stribild. The HBV drug adefovir dipivoxil (brand name: Hepsera) should not be taken with Stribild.

Avoid taking Stribild with other HIV medicines. Certain HIV medicines, if taken with Stribild, may cause serious side effects. 

While taking Stribild, it is important to keep all of your appointments with your health care provider.

What is Stribild?

Stribild is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the following uses:

  • To treat HIV infection in adults who have never taken HIV medicines before.
  • To replace the current HIV medicines (called an HIV medicine regimen) in adults who: 
    • have a viral load (the amount of HIV in a sample of blood) that is less than 50 copies/mL, and 
    • have been on the same HIV medicine regimen for at least 6 months, and 
    • have never had treatment failure (treatment failure is when an HIV medicine regimen is unable to control HIV infection), and 
    • have no drug resistance mutations associated with any of the individual drugs in Stribild (drug resistance mutations are changes in the genetic material of HIV that cause the virus to become insensitive to certain HIV medicines).

Stribild is a complete regimen for the treatment of HIV infection and should not be used with other HIV medicines. 

Stribild contains the following four different medicines combined in one pill:

  • Elvitegravir - an HIV medicine called an integrase inhibitor. 
  • Cobicistat – a medicine called a pharmacokinetic enhancer, which is used to increase the effectiveness of elvitegravir.
  • Emtricitabine – an HIV medicine called a nucleoside reverse transcriptase inhibitor (NRTI).
  • Tenofovir disoproxil fumarate – another HIV medicine (also an NRTI). 


Integrase inhibitors (such as elvitegravir) block an HIV enzyme called integrase. (An enzyme is a protein that starts or increases the speed of a chemical reaction.) NRTIs (such as emtricitabine and tenofovir disoproxil fumarate) block an HIV enzyme called reverse transcriptase. By blocking integrase and reverse transcriptase, the drugs in combination prevent HIV from multiplying and can reduce the amount of HIV in the body.

HIV medicines can’t cure HIV/AIDS, but taking a combination of HIV medicines (called an HIV treatment regimen) every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV transmission.

What should I tell my health care provider before taking Stribild?

Before taking Stribild, tell your health care provider:

  • If you are allergic to any of the HIV medicines in Stribild (elvitegravir, cobicistat, emtricitabine, or tenofovir disproxil fumarate) or any other medicines.
  • If you have liver problems, including HBV infection.
  • If you have kidney problems.
  • If you have bone problems.
  • If you have any other medical conditions.
  • If you are pregnant or plan to become pregnant. Whether Stribild can harm an unborn baby is unknown. Talk to your health care provider about possible risks with taking Stribild when pregnant.
  • If you are breastfeeding or plan to breastfeed. Do not breastfeed if you are infected with HIV or are taking Stribild.
  • If you are using hormone-based birth control (such as pills, injections, or implants).
  • About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take, including any HIV medicines. Stribild may affect the way other medicines or products work, and other medicines or products may affect how Stribild works. Taking Stribild together with certain medicines or products may cause serious and/or life-threatening side effects. Stribild should not be taken with other HIV medicines.

How should I take Stribild?

Stribild comes in tablet form. Each tablet contains:

  • 150 mg elvitegravir (brand name: Vitekta).
  • 150 mg cobicistat (brand name: Tybost).
  • 200 mg emtricitabine (brand name: Emtriva).
  • 300 mg tenofovir disproxil fumarate (brand name: Viread).

Take Stribild according to your health care provider’s instructions.

Take Stribild with food. Do not take Stribild with other HIV medicines.

If you take too much Stribild, contact your health care provider or local poison control center (1-800-222-1222) right away, or go to the nearest hospital emergency room.

For more information on how to take Stribild, see the FDA drug label from DailyMed. (DailyMed is a federal website that includes the most recent drug labels submitted to FDA.)

What should I do if I forget a dose?

If you miss a dose of Stribild, take the missed dose as soon as you remember it. But if it is almost time for your next dose, skip the missed dose and just take your next dose at the regular time. Do not take two doses at the same time to make up for a missed dose.

What side effects can Stribild cause?

Stribild can cause serious, life-threatening side effects. These include lactic acidosis (buildup of lactic acid in the blood) and liver problems. (See the WARNING above).

 Other possible side effects of Stribild include:

  • New or worsening kidney problems, including kidney failure.
  • Bone problems (bone pain, softening, or thinning [osteopenia]).
  • Changes in body fat (lipodystrophy).
  • Immune reconstitution inflammatory syndrome (IRIS), a condition that sometimes occurs when the immune system begins to recover after treatment with an HIV medicine. As the immune system gets stronger, it may have an increased response to a previously hidden infection. Tell your health care provider if you start having new symptoms after starting your HIV medicine.
  • Nausea.
  • Diarrhea.

Tell your health care provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Stribild. To learn more about possible side effects of Stribild, read the drug label or package insert or talk to your health care provider or pharmacist. 

The AIDSinfo fact sheet on HIV Medicines and Side Effects also includes information that may apply to Stribild. 

You can also report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online at

How should Stribild be stored?

  • Store Stribild at room temperature, 68°F to 77°F (20°C to 25°C).
  • Keep Stribild in the container that it came in and keep the container tightly closed. If the container has a small packet of drying agent (called a desiccant), do not remove it. The desiccant protects the medicine from moisture.
  • Do not use Stribild if the original seal over the bottle opening is broken or missing.
  • Throw away Stribild that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine. 
  • Keep Stribild and all medicines out of reach of children.

Where can I find more information about Stribild?

More information about Stribild is available:

Manufacturer Information

Gilead Sciences, Inc.

The above Patient Version drug summary is based on the following FDA label(s): Tablet.

Last Reviewed: February 19, 2015

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