Abacavir / Dolutegravir / LamivudineBrand Name: Triumeq Other Names: ABC / DTG / 3TC, abacavir sulfate / dolutegravir sodium / lamivudine Drug Class: Combination Drugs
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Triumeq can cause serious, life-threatening side effects. These include allergic reactions, buildup of
Triumeq contains abacavir, an HIV medicine. People who take abacavir-containing products, including Triumeq, may have a serious allergic reaction ( reaction) that can cause death. Your risk of this allergic reaction is much higher if you have a variation called HLA-B*5701. Your health care provider can determine with a blood test if you have this gene variation. If you get a symptom from two or more of the following groups while taking Triumeq, contact your health care provider right away to find out if you should stop taking Triumeq.
- Group 1 Symptoms: Fever
- Group 2 Symptoms: Rash
- Group 3 Symptoms: Nausea, vomiting, diarrhea, abdominal pain
- Group 4 Symptoms: General ill feeling, extreme tiredness, or achiness
- Group 5 Symptoms: Shortness of breath, cough, sore throat
Contact your health care provider right away if you have any of the following symptoms that could be signs of lactic acidosis:
- Weakness or tiredness
- Unusual muscle pain
- Trouble breathing
- Stomach pain with nausea and vomiting
- Feeling cold, especially in your arms and legs
- Dizziness or lightheadedness
- Fast or irregular heartbeat
- Yellowing of your skin or the whites of your eyes ( )
- Dark-colored urine
- Light-colored bowel movements
- Loss of appetite
- Nausea or vomiting
- Pain, aching, or tenderness on the right side of your stomach area
Some people taking Triumeq have had serious liver problems. People with a history of(HBV) or (HCV) may have an increased risk of developing new or worsening liver problems while taking Triumeq.
If you have both HIV and HBVand take Triumeq, your HBV infection may get worse (flare up) if you stop taking Triumeq. To help avoid this, take Triumeq exactly as prescribed. Do not run out of Triumeq or stop taking Triumeq without talking to your health care provider.
Worsening of liver disease (sometimes resulting in death) has occurred in people with both HIV and HCV who were taking HIV medicines and also being treated for HCV infection with ribavirin. If you are taking Triumeq and interferon with or without ribavirin and you have any new symptoms, tell your health care provider.with or without
Liver problems have also occurred in people taking Triumeq who have no history of liver disease. Liver function tests may be done before and during treatment with Triumeq.
Do not take Triumeq if you take dofetilide (a medicine used to treat an irregular heartbeat). Taking Triumeq and dofetilide can cause side effects that may be life threatening.
While taking Triumeq, it is important to keep all of your appointments with your health care provider.
What is Triumeq?
Triumeq is a prescription medicine approved by the U.S.(FDA) for the treatment of HIV infection in adults and children weighing at least 88 pounds (40 kilograms). Triumeq can be used alone as a complete or with other HIV medicines.
Triumeq contains the following three different medicines combined in one pill:
- Dolutegravir – an HIV medicine called an inhibitor
- Abacavir – an HIV medicine called a (NRTI)
- Lamivudine – another HIV medicine (also an NRTI)
Triumeq is not for use by itself in people who have or have had resistance to abacavir, dolutegravir, or lamivudine.
HIV medicines can’t cure HIV/AIDS, but taking a combination of HIV medicines (called an HIV regimen) every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV . If you are taking HIV medicines, including Triumeq, don’t cut down on, skip, or stop taking them unless your health care provider tells you to.
What should I tell my health care provider before taking Triumeq?
Before taking Triumeq, tell your health care provider:
- If you are allergic to any of the HIV medicines in Triumeq (abacavir, dolutegravir, or lamivudine) or any other medicines.
- If you have been tested and know whether you have a particular gene variation called HLA-B*5701.
- If you have or had liver problems, including B (HBV) or hepatitis C virus (HCV) infection.
- If you have kidney problems.
- If you have heart problems; smoke; or have diseases that increase your risk of heart disease, such as high blood pressure, high , or .
- If you have any other medical conditions.
- If you drink alcoholic beverages or take medicines that contain alcohol.
- If you are pregnant or plan to become pregnant. Whether Triumeq can harm an unborn baby is unknown. Talk to your health care provider about possible risks with taking Triumeq when pregnant.
- If you are breastfeeding or plan to breastfeed. Do not breastfeed if you have HIV or are taking Triumeq.
- If you are using HIV and Birth Control infographic. -based birth control (such as pills, implants, or vaginal rings). For more information about using birth control and HIV medicines at the same time, view the
- About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Triumeq may affect the way other medicines or products work, and other medicines or products may affect how Triumeq works. Taking Triumeq together with certain medicines or products may cause serious, life-threatening side effects. Do not take Triumeq if you take dofetilide. Taking Triumeq and dofetilide together can cause side effects that may be serious or life threatening.
How should I take Triumeq?
Triumeq comes in tablet form. Each tablet contains:
- 600 mg abacavir (brand name: Ziagen)
- 50 mg dolutegravir (brand name: Tivicay)
- 300 mg lamivudine (brand name: Epivir)
Take Triumeq with or without food. If you are taking any other medicines, carefully follow instructions on how to take them with Triumeq.
If you take too much Triumeq, contact your health care provider or local poison control center (1-800-222-1222) right away, or go to the nearest hospital emergency room.
For more information on how to take Triumeq, see the FDA drug label.
What should I do if I forget a dose?
If you miss a
What side effects can Triumeq cause?
Triumeq may cause side effects. Many side effects from HIV medicines, such as nausea or occasional dizziness, are manageable. See the AIDSinfo fact sheet on HIV Medicines and Side Effects for more information.
Some side effects of Triumeq can be serious. Serious side effects of Triumeq include allergic reactions, buildup of lactic acid in the blood (lactic acidosis), and severe liver problems. (See the WARNING box above.)
Other possible side effects of Triumeq include:
- New or worsening changes in certain liver function tests.
- Changes in your (called or IRIS). IRIS is a condition that sometimes occurs when the immune system begins to recover after treatment with an HIV medicine. As the immune system gets stronger, it may have an increased response to a previously hidden infection.
- Increased risk of heart attack ( ).
Tell your health care provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of Triumeq. To learn more about possible side effects of Triumeq, read the drug label or or talk to your health care provider or pharmacist.
You can report side effects to FDA MedWatch at 1-800-FDA-1088 (1-800-332-1088) or online.
How should Triumeq be stored?
- Store Triumeq at room temperature, 68°F to 77°F (20°C to 25°C).
- Keep Triumeq in the container that it came in and keep the container tightly closed and protected from moisture. If the container has a small packet of drying agent (called a desiccant), do not remove it. The desiccant protects the medicine from moisture.
- Do not use Triumeq if the original seal over the container opening is broken or missing.
- Throw away Triumeq that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine.
- Keep Triumeq and all medicines out of reach of children.
Where can I find more information about Triumeq?
More information about Triumeq is available:
Main number: 877-844-8872
Patient assistance (ViiV Connect): 844-588-3288
The above Patient Version drug summary is based on the following FDA label(s): Tablet, film coated .
Last Reviewed: July 2, 2018