CobicistatBrand Name: Tybost Other Names: COBI, c Drug Class: Pharmacokinetic Enhancers (CYP3A Inhibitors)
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What are the most important things to know about cobicistat?
Taking cobicistat with certain other medicines can cause serious, life-threatening side effects. These potential side effects include new or worse kidney problems, including kidney failure.
If you are taking cobicistat, tell your health care provider about other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products (including St. John's wort) you are taking or plan to take.
While taking cobicistat, it is important to keep all of your appointments with your health care provider.
What is cobicistat?
- When taken with atazanavir, cobicistat is FDA-approved for use in adults and children who weigh at least 77 lb (35 kg).
- When taken with darunavir, cobicistat is FDA-approved for use in adults and children who weigh at least 88 lb (40 kg).
Cobicistat is not an HIV medicine and does not treat HIV. Even if you take cobicistat and atazanavir or darunavir, you must also take all the HIV medicines prescribed by your health care provider. Do not cut down on, skip, or stop taking cobicistat or any HIV medicines unless your health care provider tells you to.
What should I tell my health care provider before taking cobicistat?
Before taking cobicistat, tell your health care provider:
- If you are allergic to cobicistat, atazanavir, darunavir, or any other medicines.
- If you have kidney problems.
- If you have problems.
- If you have any other medical conditions.
- If you are pregnant or plan to become pregnant. Talk to your health care provider about the risks and benefits of taking cobicistat during pregnancy.
- If you are breastfeeding or plan to breastfeed. Do not breastfeed if you have HIV or are taking cobicistat.
- If you are using HIV and Birth Control infographic. -based birth control (such as pills, implants, or vaginal rings). Cobicistat may make these forms of birth control less effective. Your health care provider can help you decide how to adjust your birth control while you are taking cobicistat. For more information about using birth control and HIV medicines at the same time, view the
- About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products (including St. John's wort) you are taking or plan to take. Cobicistat may affect the way other medicines or products work, and other medicines or products may affect how cobicistat works. Taking cobicistat together with atazanavir or darunavir and certain other medicines may cause serious or life-threatening side effects.
How should I take cobicistat?
Cobicistat (brand name: Tybost) comes in tablet form. Each tablet contains 150 mg of cobicistat.
Take cobicistat according to your health care provider’s instructions.
Take cobicistat with food.
If you take too much cobicistat, contact your health care provider or local poison control center (1-800-222-1222) right away, or go to the nearest hospital emergency room.
For more information on how to take cobicistat, see the FDA drug label.
What should I do if I forget a dose?
If you miss aof cobicistat, take the missed dose as soon as you remember it. But if it is almost time for your next dose, skip the missed dose and just take your next dose at the regular time. Do not take two doses at the same time to make up for the missed dose.
What side effects can cobicistat cause?
Cobicistat may cause side effects. Many side effects from HIV medicines, such as nausea or occasional dizziness, are manageable. See the AIDSinfo fact sheet on HIV Medicines and Side Effects for more information that may apply to cobicistat.
Some side effects of cobicistat can be serious. When taken with certain other medicines, cobicistat can cause new or worse kidney problems, including kidney failure.
When cobicistat is taken with atazanavir, the most common side effects include yellowing of your skin or the whites of your eyes ( ) and rash.
Tell your health care provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of cobicistat. To learn more about possible side effects of cobicistat, read the drug label oror talk to your health care provider or pharmacist.
You can report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online.
How should cobicistat be stored?
- Store cobicistat at room temperature, 68°F to 77°F (20°C to 25°C).
- Keep cobicistat in the container that it came in and keep the container tightly closed. If the container has a small packet of drying agent (called a desiccant), do not remove it. The desiccant protects the medicine from moisture.
- Do not use cobicistat if the original seal over the container opening is broken or missing.
- Throw away cobicistat that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine.
- Keep cobicistat and all medicines out of reach of children.
Where can I find more information about cobicistat?
More information about cobicistat is available:
Gilead Sciences, Inc.
Main number: 800-445-3235
Patient assistance: 800-226-2056
The above Patient Version drug summary is based on the following FDA label(s): Tablet (film coated).
Last Reviewed: May 28, 2020