Atazanavir / CobicistatBrand Name: Evotaz Other Names: ATV / COBI, atazanavir sulfate / cobicistat Drug Class: Combination Drugs
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Evotaz can cause serious, life-threatening side effects. These include heart rhythm problems, severe rash,problems, gallbladder problems, and kidney problems.
Contact your health care provider right away if you have any of the following symptoms that could be signs of heart rhythm problems:
Contact your health care provider or go to the nearest hospital emergency room right away if you develop a severe rash or a rash with any of the following symptoms:
- General feeling of discomfort or “flu-like” symptoms.
- Muscle or joint aches.
- Swelling of your face.
- (redness or swelling of the eyes).
- Mouth sores.
- A painful, warm, or red lump under your skin.
Some people taking Evotaz have had liver problems. People with a history ofB (HBV) or hepatitis C virus (HCV) or who have elevated results on liver function tests may have an increased risk of developing new or worsening liver problems while taking Evotaz. Liver function tests may be done before and during treatment with Evotaz. Contact your health care provider right away if you have any of the following symptoms that could be signs of liver problems:
- Yellowing of your skin or the whites of your eyes ( ).
- Dark-colored urine.
- Light-colored bowel movements.
- Pain in your stomach area.
Contact your health care provider right away if you have any of the following symptoms that could be signs of gallbladder problems:
- Pain in your right or middle upper stomach area.
- Nausea and vomiting.
- Yellowing of your skin or the whites of your eyes (jaundice).
Evotaz, when taken with certain other medicines, can cause new or worse kidney problems, including kidney failure. Your health care provider should check yourbefore and during treatment with Evotaz.
While taking Evotaz, it is important to keep all of your appointments with your health care provider.
What is Evotaz?
Evotaz is a prescription medicine approved by the U.S.(FDA) for the treatment of HIV infection in adults. Evotaz is always used in combination with other HIV medicines.
Evotaz contains the following two different medicines combined in one pill:
- Atazanavir – an HIV medicine called a (PI).
- Cobicistat – an HIV medicine called a pharmacokinetic enhancer (CYP3A inhibitor).
PIs, such as atazanavir, block an HIV called protease. (An enzyme is a that starts or increases the speed of a chemical reaction.) By blocking protease, PIs prevent HIV from multiplying and can reduce the amount of HIV in the body. , such as cobicistat, are used in HIV treatment to increase the effectiveness of other HIV medicines.
HIV medicines can’t cure HIV/AIDS, but taking a combination of HIV medicines (called an HIV regimen) every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV. If you are taking HIV medicines, including Evotaz, don't cut down on, skip, or stop taking them unless your health care provider tells you to.
What should I tell my health care provider before taking Evotaz?
Before taking Evotaz, tell your health care provider:
- If you are allergic to any of the HIV medicines in Evotaz (atazanavir or cobicistat) or any other medicines.
- If you have heart problems.
- If you have liver problems, including hepatitis B virus (HBV) infection and .
- If you have kidney problems.
- If you have .
- If you have .
- If you have any other medical conditions.
- If you are pregnant or plan to become pregnant. Whether Evotaz can harm an unborn baby is unknown. Evotaz should be used during pregnancy only if the potential benefits outweigh the risks. Some pregnant women have developed a severe condition called (buildup of lactic acid in the blood) when taking Evotaz with other HIV medicines called inhibitors (NRTIs). Talk to your health care provider about possible risks with taking Evotaz when pregnant.
- If you are breastfeeding or plan to breastfeed. Do not breastfeed if you are infected with HIV or are taking Evotaz.
- If you are using HIV and Birth Control infographic. -based birth control (such as pills, implants, or vaginal rings). Evotaz may make these forms of birth control less effective. Your health care provider can help you decide how to adjust your birth control while you are taking Evotaz. For more information about using birth control and HIV medicines at the same time, view the AIDSinfo
- About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products (particularly St. John's Wort) you are taking or plan to take. Evotaz may affect the way other medicines or products work, and other medicines or products may affect how Evotaz works.Taking Evotaz together with certain medicines or products may cause serious, life-threatening side effects.
How should I take Evotaz?
Evotaz comes in tablet form. Each tablet contains:
Take Evotaz according to your health care provider’s instructions.
Take Evotaz once a day with food.
Always take Evotaz in combination with other HIV medicines.
If you take too much Evotaz, contact your health care provider or local poison control center (1-800-222-1222) right away, or go to the nearest hospital emergency room.
For more information on how to take Evotaz, see the FDA drug label from DailyMed. (DailyMed is a federal website that includes the most recent drug labels submitted to FDA.)
What should I do if I forget a dose?
If you miss aof Evotaz by less than 12 hours, take your missed dose of Evotaz right away. Then take your next dose of Evotaz at your regularly scheduled time.
If you miss a dose of Evotaz by more than 12 hours, wait and then take the next dose of Evotaz at your regularly scheduled time.
If you skip a dose of Evotaz, do not double the next dose.
What side effects can Evotaz cause?
Evotaz may cause side effects. Most side effects from Evotaz are manageable, but a few can be serious. Serious side effects of Evotaz include heart rhythm problems, severe rash, liver problems, gallbladder problems, kidney problems, and life-threatening drug interactions. (See the WARNING box above.)
Other possible side effects of Evotaz include:
- Mild rash.
- and high blood sugar ( ).
- Changes in body fat (including gain or loss of fat).
- Yellowing of your skin or the whites of your eyes (jaundice), which may be caused by increased levels in your blood. Contact your health care provider right away if you have this side effect.
- Increased bleeding problems in people with hemophilia.
- (IRIS), a condition that sometimes occurs when the begins to recover after treatment with an HIV medicine. As the immune system gets stronger, it may have an increased response to a previously hidden infection.
- Kidney stones. Contact your health care provider if you have pain in your lower back or lower stomach area, blood in your urine, or pain when urinating.
Tell your health care provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of Evotaz. To learn more about possible side effects of Evotaz, read the drug label oror talk to your health care provider or pharmacist.
The AIDSinfo fact sheet on HIV Medicines and Side Effects also includes information that may apply to Evotaz.
You can report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online at https://www.accessdata.fda.gov/scripts/medwatch/.
How should Evotaz be stored?
- Store Evotaz at room temperature, 68°F to 77°F (20°C to 25°C)
- Keep Evotaz in the container that it came in and keep the container tightly closed. If the container has a small packet of drying agent (called a desiccant), do not remove it. The desiccant protects the medicine from moisture.
- Do not use Evotaz if the original seal over the container opening is broken or missing.
- Throw away Evotaz that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine.
- Keep Evotaz and all medicines out of reach of children.
Where can I find more information about Evotaz?
More information about Evotaz is available:
Main number: 800-332-2056
Patient assistance: 888-281-8981
The above Patient Version drug summary is based on the following FDA label(s): Tablet.
Last Reviewed: September 22, 2016