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Ombitasvir/Paritaprevir/Ritonavir plus Dasabuvir

Ombitasvir/Paritaprevir/Ritonavir plus Dasabuvir

Brand Name: Viekira Pak Other Names: paritaprevir/ritonavir/ombitasvir/dasabuvir Drug Class: Opportunistic Infections and Coinfections
What is Viekira Pak?

What is Viekira Pak?

Viekira Pak is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of chronic (lasting a long time) hepatitis C virus infection (HCV), including in people with a certain type of liver damage called compensated cirrhosis. Viekira Pak comes in cartons that contain two different types of tablets. One tablet contains the medicines ombitasvir, paritaprevir, and ritonavir. The other tablet contains the medicine dasabuvir.

HCV is an opportunistic infection (OI). An OI is an infection that occurs more frequently or is more severe in people with weakened immune systems—such as people with HIV—than in people with healthy immune systems. To learn more about OIs, read the AIDSinfo What is an Opportunistic Infection? fact sheet.

To learn how HIV and HCV are connected, read the AIDSinfo HIV and Hepatitis C fact sheet. The fact sheet includes information about how HCV is spread, symptoms of HCV, and treatment options.

How is Viekira Pak used in people with HIV?

How is Viekira Pak used in people with HIV?

The Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents (the Guidelines) and the Hepatitis C Guidance: AASLD-IDSA Recommendations for Testing, Managing, and Treating Adults Infected with Hepatitis C Virus (the Guidance) both include recommendations on the HIV-related use of Viekira Pak.

Using a medicine as indicated on the medicine label is called on-label use; using the medicine in a different way is called off-label use. Off-label use, for example, can include using a drug for a different disease or medical condition. Good medical practice and the best interests of a patient sometimes require that a medicine be used off-label.

The Guidelines and the Guidance include recommendations on both the on-label use and off-label use of Viekira Pak in people with HIV:

  • On-label use: treatment of chronic HCV
  • Off-label use: treatment of acute HCV
The HIV-related uses of Viekira Pak listed above may not include all the uses of the medicine recommended in the Guidelines and the Guidance. Some recommended uses, such as uses in certain rare circumstances, may have been omitted.

What should I tell my health care provider before taking Viekira Pak?

What should I tell my health care provider before taking Viekira Pak?

Before taking Viekira Pak, tell your health care provider:

  • If you are allergic to any of the medicines in Viekira Pak (dasabuvir, ombitasvir, paritaprevir, and ritonavir) or any other medicines.
  • About any medical conditions you have or have had, for example, diabetes or liver problems.
  • About anything that could affect your ability to take medicines, such as difficulty swallowing or remembering to take pills.
  • If you are pregnant or plan to become pregnant. Whether Viekira Pak can harm an unborn baby is unknown. Viekira Pak should be used during pregnancy only if clearly needed. Sometimes Viekira Pak is taken with the HIV medicine ribavirin. Ribavirin may cause birth defects or death of an unborn baby. Pregnant women and men whose partners are pregnant should not use Viekira Pak with ribavirin. Talk to your health care provider about possible risks with taking Viekira Pak when pregnant.
  • If you are breastfeeding or plan to breastfeed. Do not breastfeed if you have HIV.
  • About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Viekira Pak may affect the way other medicines or products work, and other medicines or products may affect how Viekira Pak works. Ask your health care provider if there are interactions between Viekira Pak and the other medicines you take.

Ask your health care provider about possible side effects from Viekira Pak. Your health care provider will tell you what to do if you have side effects.

How should I take Viekira Pak?

How should I take Viekira Pak?

Take Viekira Pak according to your health care provider’s instructions. Your health care provider will tell you how much of Viekira Pak to take and when to take it. Before you start Viekira Pak and each time you get a refill, read any printed information that comes with your medicine. If you take the medicine ribavirin along with Viekira Pak, also read any printed information that comes with your ribavirin medicine.

How should Viekira Pak be stored?

How should Viekira Pak be stored?

  • Store Viekira Pak at or below 86°F (30°C).
  • Do not use Viekira Pak if the seal on the top of the carton is broken.
  • Throw away Viekira Pak that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine.
  • Keep Viekira Pak and all medicines out of reach of children.

Where can I find more information about Viekira Pak?

Where can I find more information about Viekira Pak?

More information about Viekira Pak is available:

 

The above Patient Version drug summary is based on the following FDA label(s): Co-packaged tablets (film coated).

Last Reviewed: May 8, 2018