Genvoya can cause serious, life-threatening side effects. These include lactic acidosis (buildup of lactic acid in the blood) and liver problems.
Contact your health care provider right away if you have any of the following symptoms that could be signs of lactic acidosis:
Some people taking Genvoya have had liver problems. People with a history of hepatitis B virus (HBV) infection or people who have elevated results on liver function tests may have an increased risk of developing new or worsening liver problems while taking Genvoya. Liver problems have also occurred in people taking Genvoya who have no history of liver disease. Liver function tests may be done before and during treatment with Genvoya.
Contact your health care provider right away if you have any of the following symptoms that could be signs of liver problems:
Genvoya is not approved for the treatment of HBV infection. If you have both HIV and HBV infection and take Genvoya, your HBV infection may get worse (flare up) if you stop taking Genvoya. The HBV drug adefovir dipivoxil (brand name: Hepsera) should not be taken with Genvoya.
If you take Genvoya, you should not take other HIV medicines.
While taking Genvoya, it is important to keep all of your appointments with your health care provider.
Genvoya is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the following uses:
Genvoya is a complete regimen for the treatment of HIV infection and should not be used with other HIV medicines.
Genvoya contains the following four different medicines combined in one pill:
Integrase inhibitors (such as elvitegravir) block an HIV enzyme called integrase. (An enzyme is a protein that starts or increases the speed of a chemical reaction.) NRTIs (such as emtricitabine and tenofovir alafenamide fumarate) block an HIV enzyme called reverse transcriptase. By blocking integrase and reverse transcriptase, the drugs in combination prevent HIV from multiplying and can reduce the amount of HIV in the body.
HIV medicines can’t cure HIV/AIDS, but taking a combination of HIV medicines (called an HIV regimen) every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV transmission. If you are taking HIV medicines, including Genvoya, don’t cut down on, skip, or stop taking them unless your health care provider tells you to.
Before taking Genvoya, tell your health care provider:
Genvoya comes in tablet form. Each tablet contains:
Take Genvoya according to your health care provider’s instructions.
Take Genvoya with food. Do not take Genvoya with other HIV medicines.
If you need to take a medicine for indigestion (an antacid) that contains aluminum and magnesium hydroxide or calcium carbonate during treatment with Genvoya, take it at least 2 hours before or after you take Genvoya.
If you take too much Genvoya, contact your health care provider or local poison control center (1-800-222-1222) right away, or go to the nearest hospital emergency room.
For more information on how to take Genvoya, see the FDA drug label from DailyMed. (DailyMed is a federal website that includes the most recent drug labels submitted to FDA.)
If you miss a dose of Genvoya, take the missed dose as soon as you remember it. But if it is almost time for your next dose, skip the missed dose and just take your next dose at the regular time. Do not take two doses at the same time to make up for a missed dose. It is important to avoid missing doses.
Genvoya may cause side effects. Most side effects from Genvoya are manageable, but a few can be serious. Serious side effects of Genvoya include lactic acidosis (buildup of lactic acid in the blood) and liver problems. (See the WARNING above.)
Other possible side effects of Genvoya include:
Tell your health care provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of Genvoya. To learn more about possible side effects of Genvoya, read the drug label or package insert or talk to your health care provider or pharmacist.
The AIDSinfo fact sheet on HIV Medicines and Side Effects also includes information that may apply to Genvoya.
You can also report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online at https://www.accessdata.fda.gov/scripts/medwatch/.
More information about Genvoya is available:
Gilead Sciences, Inc.
Main number: 800-445-3235
Patient assistance: 800-226-2056
Last Reviewed: September 12, 2016