Drugs

Daclatasvir

Daclatasvir

Brand Name: Daklinza Other Names: DCV, daclatasvir dihydrochloride Drug Class: Opportunistic Infections and Coinfections
What is daclatasvir?

What is daclatasvir?

Daclatasvir is an antiviral prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of chronic (lasting a long time) hepatitis C virus infection (HCV). Daclatasvir is used in combination with other antiviral medications and should not be taken by itself.

HCV is an opportunistic infection (OI) of HIV. An OI is an infection that occurs more frequently or is more severe in people with weakened immune systems—such people with HIV—than in people with healthy immune systems. To learn more about OIs, read the AIDSinfo What is an Opportunistic Infection? fact sheet.

To learn how HIV and HCV are connected, read the AIDSinfo HIV and Hepatitis C fact sheet. The fact sheet includes information about how HCV is spread, symptoms of HCV, and treatment options.

How is daclatasvir used in people with HIV?

How is daclatasvir used in people with HIV?

The Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents and the Hepatitis C Guidance: AASLD IDSA Recommendations for Testing, Managing, and Treating Adults Infected with Hepatitis C Virus both include recommendations on the HIV-related uses of daclatasvir to treat HCV infection.

Using a medicine as indicated on the medicine label is called on-label use; using the medicine in a different way is called off-label use. Off-label use, for example, can include using a drug for a different disease or medical condition. Good medical practice and the best interests of a patient sometimes require that a medicine be used off-label.

The guidelines include recommendations on the following uses of daclatasvir:
  • On-label use: treatment of chronic HCV
  • Off-label use: treatment of acute HCV

This may not include all of the HIV-related uses of daclatasvir recommended in the guidelines. Some recommended uses, such as uses in certain rare circumstances, may have been omitted.

What should I tell my health care provider before taking daclatasvir?

What should I tell my health care provider before taking daclatasvir?

Before taking daclatasvir, tell your health care provider:

  • If you are allergic to daclatasvir or any other medicines.
  • About any other medical conditions you have or have had, including current or prior hepatitis B virus infection.
  • About anything that could affect your ability to take medicines, such as difficulty swallowing or remembering to take tablets.
  • If you are pregnant or plan to become pregnant. Whether daclatasvir can harm an unborn baby is unknown. Talk to your health care provider about possible risks with taking daclatasvir when pregnant. Sometimes daclatasvir is taken with the HIV medicine ribavirin. Ribavirin may cause birth defects or death of an unborn baby. Pregnant women and men whose partners are pregnant should not use daclatasvir with ribavirin. Women should also not become pregnant for 6 months after they stop taking ribavirin or for 6 months after their male partners stop taking ribavirin.
  • If you are breastfeeding or plan to breastfeed. Do not breastfeed if you have HIV.
  • About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Daclatasvir may affect the way other medicines or products work, and other medicines or products may affect how daclatasvir works. Ask your health care provider if there are interactions between daclatasvir and the other medicines you take.

Ask your health care provider about possible side effects from daclatasvir. Your health care provider will tell you what to do if you have side effects.

How should I take daclatasvir?

How should I take daclatasvir?

Take daclatasvir with sofosbuvir or with sofosbuvir and ribavirin. You should not take daclatasvir by itself.

Take daclatasvir according to your health care provider’s instructions. Your health care provider will tell you how much daclatasvir to take and when to take it. Before you start daclatasvir and each time you get a refill, read any printed information that comes with your medicine.

How should daclatasvir be stored?

How should daclatasvir be stored?

  • Store daclatasvir at room temperature, 68°F to 77°F (20°C to 25°C).
  • Do not use daclatasvir if the original seal over the bottle opening is broken or missing.
  • Throw away daclatasvir that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine.
  • Keep daclatasvir and all medicines out of reach of children.

Where can I find more information about daclatasvir?

Where can I find more information about daclatasvir?

More information about daclatasvir is available:

The above Patient Version drug summary is based on the following FDA label(s): Tablet.

Last Reviewed: July 24, 2018

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