Drugs

Elbasvir / Grazoprevir

Elbasvir / Grazoprevir

Brand Name: Zepatier Other Names: ELB / GRZ Drug Class: Opportunistic Infections and Coinfections
What is elbasvir/grazoprevir?

What is elbasvir/grazoprevir?

Elbasvir/grazoprevir is an antiviral prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of chronic (lasting a long time) hepatitis C virus infection (HCV).

HCV is an opportunistic infection (OI) of HIV. An OI is an infection that occurs more frequently or is more severe in people with weakened immune systems—such people with HIV—than in people with healthy immune systems. To learn more about OIs, read the AIDSinfo What is an Opportunistic Infection? fact sheet.

To learn how HIV and HCV are connected, read the AIDSinfo HIV and Hepatitis C fact sheet. The fact sheet includes information about how HCV is spread, symptoms of HCV, and treatment options.

How is elbasvir/grazoprevir used in people with HIV?

How is elbasvir/grazoprevir used in people with HIV?

The Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents (the Guidelines) and the Hepatitis C Guidance: AASLD-IDSA Recommendations for Testing, Managing, and Treating Adults Infected with Hepatitis C Virus (the Guidance) both include recommendations on the HIV-related uses of elbasvir/grazoprevir.

Using a medicine as indicated on the medicine label is called on-label use; using the medicine in a different way is called off-label use. Off-label use, for example, can include using a drug for a different disease or medical condition. Good medical practice and the best interests of a patient sometimes require that a medicine be used off-label.

The Guidelines and the Guidance include recommendations on both the on-label use and off-label use of elbasvir/grazoprevir in people with HIV:
  • On-label use: treatment of chronic HCV infection
  • Off-label use: treatment of acute HCV infection

The HIV-related uses of elbasvir/grazoprevir listed above may not include all the uses of the medicine recommended in the Guidelines and the Guidance. Some recommended uses, such as uses in certain rare circumstances, may have been omitted.

What should I tell my health care provider before taking elbasvir/grazoprevir?

What should I tell my health care provider before taking elbasvir/grazoprevir?

Before taking elbasvir/grazoprevir, tell your health care provider:

  • If you are allergic to elbasvir, grazoprevir, or any other medicines.
  • About any medical conditions you have or have had, especially hepatitis B virus infection (HBV) or liver problems other than HCV infection.
  • If you have ever taken any medicine for HCV infection.
  • If you have had or are waiting for a liver transplant.
  • If you take any of the following medicines: cobicistat, efavirenz, etravirine, nevirapine, or any HIV protease inhibitors.
  • About anything that could affect your ability to take medicines, such as difficulty swallowing or remembering to take tablets.
  • If you are pregnant or plan to become pregnant. Whether elbasvir/grazoprevir can harm an unborn baby is unknown. Talk to your health care provider about possible risks with taking elbasvir/grazoprevir when pregnant. Sometimes elbasvir/grazoprevir is taken with the HIV medicine ribavirin. Ribavirin may cause birth defects or death of an unborn baby. Pregnant women and men whose partners are pregnant should not use elbasvir/grazoprevir with ribavirin. Women should also not become pregnant for 6 months after they stop taking ribavirin or for 6 months after their male partners stop taking ribavirin.
  • If you are breastfeeding or plan to breastfeed. Do not breastfeed if you have HIV.
  • About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Elbasvir/grazoprevir may affect the way other medicines or products work, and other medicines or products may affect how elbasvir/grazoprevir works. Ask your health care provider if there are interactions between elbasvir/grazoprevir and the other medicines you take.

Ask your health care provider about possible side effects from elbasvir/grazoprevir. Your health care provider will tell you what to do if you have side effects.

How should I take elbasvir/grazoprevir?

How should I take elbasvir/grazoprevir?

Take elbasvir/grazoprevir according to your health care provider’s instructions. Your health care provider will tell you how much elbasvir/grazoprevir to take and when to take it. Before you start elbasvir/grazoprevir and each time you get a refill, read any printed information that comes with your medicine.

How should elbasvir/grazoprevir be stored?

How should elbasvir/grazoprevir be stored?

  • Store elbasvir/grazoprevir at room temperature, 68°F to 77°F (20°C to 25°C).
  • Do not use elbasvir/grazoprevir if the original package seal is broken.
  • Throw away elbasvir/grazoprevir that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine.
  • Keep elbasvir/grazoprevir and all medicines out of reach of children.

Where can I find more information about elbasvir/grazoprevir?

Where can I find more information about elbasvir/grazoprevir?

More information about elbasvir/grazoprevir is available:

The above Patient Version drug summary is based on the following FDA label(s): Tablet (film coated).

Last Reviewed: April 24, 2018