Sofosbuvir/VelpatasvirOther Names: Epclusa, SOF/VLP Drug Class: Opportunistic Infections and Coinfections
What is sofosbuvir/velpatasvir?
Sofosbuvir/velpatasvir is a prescription medicine approved by the U.S. (FDA) for the treatment of chronic (lasting a long time) (HCV).
HCV is an (OI) of HIV. An OI is an that occurs more frequently or is more severe in people with weakened immune systems—such as people with HIV—than in people with healthy immune systems. To learn more about OIs, read the What is an Opportunistic Infection? fact sheet.
To learn how HIV and HCV are connected, read the AIDSinfo HIV and Hepatitis C fact sheet.
How is sofosbuvir/velpatasvir used in people with HIV?
The Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV refer readers to the HCV Guidance: Recommendations for Testing, Managing, and TreatingC for recommendations on the treatment of HCV in people with HIV.
The HCV guidance includes recommendations on the uses of sofosbuvir/velpatasvir to treat both acute and chronic HCV infection in people with HIV.
The recommended uses may not always be consistent with FDA-approved uses of sofosbuvir/velpatasvir. See the guidelines for complete information on recommended uses of sofosbuvir/velpatasvir in adults and adolescents with HIV. Some recommended uses, such as uses in certain rare circumstances, may have been omitted above.
What should I tell my health care provider before taking sofosbuvir/velpatasvir?
Before taking sofosbuvir/velpatasvir, tell your health care provider:
- If you are allergic to sofosbuvir/velpatasvir or any other medicines.
- About any medical conditions you have or have had, especially (HBV) and any other problems in addition to HCV infection.
- If you have severe kidney problems or you are on dialysis.
- About anything that could affect your ability to take medicines, such as difficulty swallowing or remembering to take pills.
- If you are pregnant or plan to become pregnant. Whether sofosbuvir/velpatasvir can harm an unborn baby is unknown. Talk to your health care provider about possible risks with taking sofosbuvir/velpatasvir when pregnant. Sometimes sofosbuvir/velpatasvir is taken with the medicine ribavirin. Because ribavirin may cause birth defects or death of an unborn baby, sofosbuvir/velpatasvir with ribavirin should not be used by pregnant women or by men whose partners are pregnant. Women should also not become pregnant for 6 months after they (or their male partners) stop taking ribavirin (with or without sofosbuvir/velpatasvir).
- If you are breastfeeding or plan to breastfeed. Do not breastfeed if you have HIV.
- About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Sofosbuvir/velpatasvir may affect the way other medicines or products work, and other medicines or products may affect how sofosbuvir/velpatasvir works. Ask your health care provider if there are interactions between sofosbuvir/velpatasvir and the other medicines you take.
How should I take sofosbuvir/velpatasvir?
Take sofosbuvir/velpatasvir according to your health care provider’s instructions. Your health care provider will tell you how much sofosbuvir/velpatasvir to take and when to take it. Before you start sofosbuvir/velpatasvir and each time you get a refill, read any printed information that comes with your medicine.
How should sofosbuvir/velpatasvir be stored?
- Store sofosbuvir/velpatasvir at room temperature, below 86°F (30°C).
- Keep sofosbuvir/velpatasvir in the container that it came in and keep the container tightly closed.
- Do not use sofosbuvir/velpatasvir if the original seal over the container opening is broken or missing.
- Throw away sofosbuvir/velpatasvir that is no longer needed or expired (out of date).
- Follow FDA guidelines on how to safely dispose of unused medicine.
- Keep sofosbuvir/velpatasvir and all medicines out of reach of children.
Where can I find more information about sofosbuvir/velpatasvir?
More information about sofosbuvir/velpatasvir is available:
- Recommendations on the HIV-related uses of sofosbuvir/velpatasvir, from the Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV, prepared by the , the , and the HIV Medicine Association of the Diseases Society of America
- Recommendations on the HIV-related uses of sofosbuvir/velpatasvir, from the HCV Guidance: Recommendations for Testing, Managing, and Treating Hepatitis C, prepared by the American Association for the Study of Liver Diseases and the Infectious Diseases Society of America
- Sofosbuvir/velpatasvir-related research studies, from the AIDSinfo database of study summaries
The above Patient Version drug summary is based on the following FDA label(s): Tablet (film-coated).
Last Reviewed: July 10, 2019