skip to content


Issue No. 20 | May 4, 2007

News and Features

HIV "Entry Claw" Visualized by National Cancer Institute Researchers

Researchers at the National Cancer Institute (NCI) have used advanced molecular imaging techniques to visualize the structure that forms between HIV and the cell it is infecting.

The "entry claw," as it has been called by the NCI researchers, is a structure unique to the process HIV uses to enter cells. Visualizing this structure may lead to the development of new drugs that can block the entry of HIV into immune cells. The discovery of HIV's physical means of entering immune cells also raises more questions on the physical makeup of the structure and, more specifically, how this structure functions in the viral entry process.

The study was led by Sriram Subramaniam, Ph.D., of the Laboratory of Cell Biology at NCI's Center for Cancer Research and was published in the May 4, 2007, issue of PLoS Pathogens.

For more information and to see both an actual image of HIV forming an entry claw, including a graphic representation of the process, please see the complete NIH press release.

2007 National Conference on Latinos and AIDS

The 2007 National Conference on Latinos and AIDS will take place July 30-31, in Miami Beach, Florida. The featured speaker this year is Rosie Perez.

This conference is a national forum on HIV/AIDS for health professionals who provide care for Latino communities. It will help health care providers update their knowledge, skills, and attitudes about HIV/AIDS. The conference was also designed for healthcare media, federal and state legislators, AIDS service organization officers, social workers, pharmacists, nurses, peer counselors, church leadership, and corrections health care personnel.

The aims of this conference are to inform participants about the epidemiology of HIV; current HIV research and guidelines; modern methods for the management of HIV; social and psychiatric concerns of HIV infected patients; and political issues, trends, and policy initiatives that impact HIV infected patients.

Conference topics this year include:

1. Clinical Management Strategies
2. Transgender Health
3. STDs in Women and Men
4. Management of Hepatitis B and C
5. Drug Resistant TB
6. OB/GYN Considerations
7. HIV and Substance Abuse
8. Vaccine Updates

Read more about the program schedule.

Register online or get more information about this important event.

View the printable conference brochure:

The 2007 National Conference on Latinos and AIDS is sponsored in part by the National Institutes of Health and the Office of AIDS Research.

Reminder: Supplement to the Guidelines for the Use of Antiretroviral Agents in HIV-1 Infected Adults and Adolescents Released

On Monday, April 30, the Department of Health and Human Services Panel on Antiretroviral Guidelines for Adults and Adolescents released the following supplement to the Adult and Adolescent Treatment Guidelines:

Entecavir in Hepatitis B Virus (HBV)/HIV Co-infected Patients

Previously, the guidelines recommended entecavir as an option for patients who required treatment for Hepatitis B virus (HBV) but not HIV infection. This recommendation was based on in vitro data showing no significant activity of entecavir against HIV-1. A recent case series of three patients who received entecavir without concomitant antiretroviral therapy reported a 1 log10 decline in HIV-RNA levels and emergence of M184V mutations in one patient who was studied in detail.

Based on these preliminary findings, the Panel recommends that:

For HBV/HIV co-infected patients, entecavir should not be used for the treatment of HBV infection without concomitant treatment for HIV.

Download the full supplement alone or with the complete Adult Guidelines in PDF or PDA format.