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Issue No. 31 | July 30, 2010

News and Features

CDC Updates HIV/AIDS Basic Statistics Web Page

The Centers for Disease Control and Prevention (CDC) recently updated the HIV Infection and AIDS Basic Statistics Web page with information from the HIV Surveillance Report: Diagnoses of HIV infection and AIDS in the United States and Dependent Areas, 2008. This page provides information and statistics on HIV/AIDS in the United States, including statistical breakdowns of HIV and AIDS diagnoses by age, race/ethnicity, and transmission methods. The page also provides links to Web sites to find HIV infection data by state and links to locate international HIV/AIDS statistics.

Study Suggests Long-Term Increases in CD4 Counts Occur in HIV-Infected People Receiving ART

“To inform guidelines concerning when to initiate combination antiretroviral therapy (ART), [study researchers] investigated whether CD4(+) T-cell counts (CD4 cell counts) continue to increase over long periods of time on ART. … [Study researchers] estimated the long-term CD4 cell count trajectory accounting for losses-to-follow-up and treatment discontinuations. … The study population included 898 US patients first initiating ART in a randomized trial (AIDS Clinical Trials Group 384); 575 were subsequently prospectively followed in an observational study (AIDS Clinical Trials Group Longitudinal Linked Randomized Trials). … Inverse probability of censoring weighting statistical methods were used to estimate the CD4 cell count trajectory accounting for losses-to-follow-up and ART discontinuations, overall and for pretreatment CD4 cell count categories (<or=200, 201-350, 351-500, and >500 cells/microl). … Median CD4 cell count increased from 270 cells/microl pre-ART to an estimated 556 cells/microl at 3 and 532 cells/microl at 7 years after starting ART in analyses ignoring treatment discontinuations, and to 570 and 640 cells/microl, respectively, had all patients continued ART. However, even had ART been continued, an estimated 25, 9, 3, and 2% of patients with pretreatment CD4 cell counts of 200 or less, 201-350, 351-500, and more than 500 cells/microl would have had CD4 cell counts of 350 cells/microl or less after 7 years. … If patients remain on ART, CD4 cell counts increase in most patients for at least 7 years. However, the substantial percentage of patients starting therapy at low CD4 cell counts who still had low CD4 cell counts after 7 years provides support for ART initiation at higher CD4 cell counts.”

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