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Issue No. 4 | January 21, 2011

News and Features

CDC Updates AIDS Surveillance - Trends Slide Set

The Centers for Disease Control and Prevention (CDC) recently updated the “AIDS Surveillance - Trends (1985-2008)” slide set with information from the HIV Surveillance Report: Diagnoses of HIV infection and AIDS in the United States and Dependent Areas, 2008. The slide set provides information on AIDS diagnoses in the United States, including breakdowns of AIDS diagnoses by race/ethnicity and transmission methods.

Study Identifies PD-1 as a Unique Marker of Failing Immune Reconstitution in HIV-Infected Individuals Receiving Treatment

“PD-1 expression on T cells correlates with T-cell exhaustion and disease progression in HIV-infected patients. Previous studies have shown that combinational antiretroviral therapy induced viral suppression results in immune restoration and reduced PD-1 expression. However, a significant number of patients fail to restore CD4 T cells despite suppression of HIV replication below limit of quantification. In this study, we have analyzed PD-1 expression on CD4 and CD8 T cells in patients with poor immune reconstitution despite successful highly active antiretroviral therapy. We found that T cells of such patients express significantly higher levels of PD-1 than patients who had normal recovery of CD4 cells after treatment. In contrast, failing immune reconstitution was not associated with the expression of activation markers, indicating that PD-1 is a unique marker for failing immune reconstitution despite viral suppression. … PD-1 expression negatively correlated with individual CD4 cell counts, and PD-1 expressing T cells were more prone to programmed death ligand-mediated inhibition of T-cell proliferation, indicating that PD-1-mediated T-cell suppression may have a role in impaired immune reconstitution in HIV patients.”

More information is available: