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Issue No. 54 | December 16, 2011

News and Features

AIDSinfo Offers User-Friendly Clinical Trials Search

Are you interested in participating in an HIV/AIDS-related clinical trial but aren’t sure how to locate one? The AIDSinfo clinical trial search offers easy access to the HIV/AIDS-related clinical trials registered in Visitors to the AIDSinfo and infoSIDA clinical trials search pages have 2-click access to more than 80 predesigned searches for HIV/AIDS-related trials in 10 different categories, including cancer, coinfections, complications/side effects, opportunistic infections, prevention research, specific populations, treatment research, vaccine research, trials by age, and trials by study type.

In addition to the predesigned searches, users can also create a completely customized search for trials, including searching by keyword, recruitment status, location, and several additional fields.

If you need assistance searching for clinical trials, AIDSinfo health information specialists are available by phone (800-448-0440) or through our Live Chat service.

Study Suggests Increased Risk for Coronary Events in Some People Infected with HIV

“HIV infection and exposure to certain antiretroviral drugs is associated with dyslipidemia and increased risk for coronary events. Whether this risk is mediated by highly atherogenic lipoproteins is unclear. [Study researchers] investigated the association of highly atherogenic small dense low density lipoproteins (LDL) and apolipoprotein B and coronary events in HIV-infected individuals receiving antiretroviral therapy. …

“[Study researchers] conducted a case control study nested into the Swiss HIV Cohort Study to investigate the association of small dense LDL and apolipoprotein B and coronary events in 98 antiretroviral drug treated patients with a first coronary event (19 fatal and 79 non-fatal coronary events with 53 definite and 15 possible myocardial infarctions, 11 angioplasties or bypasses) and 393 treated controls matched for age, gender and smoking status. …

“In models including cholesterol, triglycerides, HDL-cholesterol, blood pressure, central obesity, diabetes and family history, there was an independent association between small dense LDL and coronary events (odds ratio (OR) for 1 mg/dL increase: 1.06, 95% CI 1.00-1.11) and apolipoprotein B (OR for 10 mg/dL increase: 1.16, 95% CI 1.02-1.32). When adding HIV and antiretroviral therapy related variables ORs were 1.04 (95%CI 0.99-1.10) for small dense LDL and 1.13, (95%CI 0.99-1.30) for apolipoprotein B. In both models blood pressure and HIV viral load was independently associated with the odds for coronary events. …

“HIV-infected patients receiving antiretroviral therapy with elevate small dense LDL and apolipoprotein B are at increased risk for coronary events as are patients without sustained HIV suppression.”

More information is available: