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Issue No. 28 | July 8, 2011

News and Features

CDC Updates “HIV Surveillance in Injection Drug Users” Slide Set

The Centers for Disease Control and Prevention (CDC) recently updated the HIV Surveillance in Injection Drug Users (through 2009)” slide set with information from the 2009 HIV Surveillance Report. The slide set provides information on diagnoses of HIV infection and AIDS in injection drug users in the United States and dependent areas, including breakdowns of diagnoses by transmission category, sex, race/ethnicity, and age group.

Summer 2011 Issue of mental health AIDS Now Available

The quarterly biopsychosocial research update on HIV and mental health, mental health AIDS, is sponsored by the Center for Mental Health Services (CMHS) of the Substance Abuse and Mental Health Services Administration (SAMHSA) and is disseminated free of charge through the SAMHSA Web site.

The Summer 2011 issue features an article titled, “Positively Golden: Advances in Aging with HIV (Part 1).”

It is estimated that by 2015 about half of the adults living with HIV/AIDS in the United States will be 50 years of age or older. Many HIV-infected older adults experience depressive symptoms, suicidal ideation, HIV-related stigma, and a variety of comorbid health conditions; however, mental health interventions tailored specifically for this population are essentially nonexistent.

This is the first article in a two-part series. In this article, recent research findings on medical and neurocognitive concerns associated with HIV and aging are highlighted. A characterization of “successful cognitive aging” with HIV is presented, as are performance-based measures to identify functional impairment associated with aging and HIV. The article also discusses cognitive remediation strategies for use with older HIV-infected people who exhibit cognitive decline.

More information is available:

Research Suggests Mitochondrial Aging is Accelerated by Antiretroviral Therapy

“There is emerging evidence that people with successfully treated HIV infection age prematurely, leading to progressive multi-organ disease, but the reasons for this are not known. Here we show that patients treated with commonly used nucleoside analog anti-retroviral drugs progressively accumulate somatic mitochondrial DNA (mtDNA) mutations, mirroring those seen much later in life caused by normal aging. Ultra-deep re-sequencing by synthesis, combined with single-cell analyses, suggests that the increase in somatic mutation is not caused by increased mutagenesis but might instead be caused by accelerated mtDNA turnover. This leads to the clonal expansion of preexisting age-related somatic mtDNA mutations and a biochemical defect that can affect up to 10% of cells. These observations add weight to the role of somatic mtDNA mutations in the aging process and raise the specter of progressive iatrogenic mitochondrial genetic disease emerging over the next decade.”

More information is available: